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In Vitro Modeling of Mechanics in Cancer Metastasis

Malandrino, A; Kamm, RD; Moeendarbary, E; (2018) In Vitro Modeling of Mechanics in Cancer Metastasis. ACS Biomaterials Science & Engineering , 4 (2) pp. 294-301. 10.1021/acsbiomaterials.7b00041. Green open access

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Abstract

In addition to a multitude of genetic and biochemical alterations, abnormal morphological, structural, and mechanical changes in cells and their extracellular environment are key features of tumor invasion and metastasis. Furthermore, it is now evident that mechanical cues alongside biochemical signals contribute to critical steps of cancer initiation, progression, and spread. Despite its importance, it is very challenging to study mechanics of different steps of metastasis in the clinic or even in animal models. While considerable progress has been made in developing advanced in vitro models for studying genetic and biological aspects of cancer, less attention has been paid to models that can capture both biological and mechanical factors realistically. This is mainly due to lack of appropriate models and measurement tools. After introducing the central role of mechanics in cancer metastasis, we provide an outlook on the emergence of novel in vitro assays and their combination with advanced measurement technologies to probe and recapitulate mechanics in conditions more relevant to the metastatic disease.

Type: Article
Title: In Vitro Modeling of Mechanics in Cancer Metastasis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsbiomaterials.7b00041
Publisher version: https://doi.org/10.1021/acsbiomaterials.7b00041
Language: English
Additional information: This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Keywords: 3D microenvironment; biomaterials; cancer mechanobiology; extravasation; invasive tumour; microfluidics; traction forces
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10038264
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