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Resolving the clinico-radiological paradox in multiple sclerosis

Chard, D; Trip, SA; (2017) Resolving the clinico-radiological paradox in multiple sclerosis. F1000Research , 6 , Article 1828. 10.12688/f1000research.11932.1. Green open access

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Abstract

Understanding the clinico-radiological paradox is important in the search for more sensitive and specific surrogates of relapses and disability progression (such that they can be used to inform treatment choices in individual people with multiple sclerosis) and to gain a better understanding of the pathophysiological basis of disability in multiple sclerosis (to identify and assess key therapeutic targets). In this brief review, we will consider themes and issues underlying the clinico-radiological paradox and recent advances in its resolution.

Type: Article
Title: Resolving the clinico-radiological paradox in multiple sclerosis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.12688/f1000research.11932.1
Publisher version: https://doi.org/10.12688/f1000research.11932.1
Language: English
Additional information: This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: MRI, clinico-radiological paradox, multiple sclerosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10037747
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