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Functional interplay between posterior parietal and ipsilateral motor cortex revealed by twin-coil TMS during reach planning toward contralateral space.

Koch, G; Del Olmo, MF; Cheeran, B; Schippling, S; Caltagirone, C; Driver, J; Rothwell, J; (2008) Functional interplay between posterior parietal and ipsilateral motor cortex revealed by twin-coil TMS during reach planning toward contralateral space. Journal of Neuroscience , 28 (23) 5944 -5953. 10.1523/​JNEUROSCI.0957-08.2008. Green open access

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Abstract

Posterior parietal cortex (PPC) has connections with motor and premotor cortex, thought to transfer information relevant for planning movements in space. Using twin coil transcranial magnetic stimulation (tcTMS) methods to examine functional interplay between human right PPC and ipsilateral motor cortex (M1), here we show that this interplay varies with current motor plans. tcTMS during the planning phase of a reach task revealed facilitatory influences of right PPC on right M1 only when planning a (contralateral) leftward rather than rightward reach, at two specific time intervals (50ms and 125 ms) after an auditory cue. The earlier reach-direction-specific facilitatory influence from PPC on M1 was replicated with subjects blindfolded or when the targets were presented briefly, so that visual feedback did not occur. Within the left hemisphere, PPC-M1 interplay showed a similar profile but now specific to (contralateral) rightward planned reaches, with peaks at 50 and 100 ms. Functional interplay between human parietal and motor cortex is enhanced during early stages of planning a reach in the contralateral direction.

Type: Article
Title: Functional interplay between posterior parietal and ipsilateral motor cortex revealed by twin-coil TMS during reach planning toward contralateral space.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/​JNEUROSCI.0957-08.2008
Publisher version: http://dx.doi.org/10.1523/​JNEUROSCI.0957-08.2008
Language: English
Additional information: This work is licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The license allows you to copy, distribute, and transmit the work, as well as adapting it. However, you must attribute the work to the author (but not in any way that suggests that they endorse you or your use of the work), and cannot use the work for commercial purposes without prior permission of the author. If you alter or build upon this work, you can distribute the resulting work only under the same or similar license to this one. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/100368
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