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Atherosclerosis in systemic lupus erythematosus

Croca, S; Rahman, A; (2017) Atherosclerosis in systemic lupus erythematosus. Best Practice & Research Clinical Rheumatology , 31 (3) pp. 364-372. 10.1016/j.berh.2017.09.012. Green open access

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Abstract

Cardiovascular disease (CVD), comprising coronary heart disease and stroke, is one of the most important causes of death in patients with systemic lupus erythematosus (SLE). The risks of developing both clinical CVD and sub-clinical atherosclerosis are increased in patients with SLE. This increase is not fully explained by traditional cardiovascular risk factors such as smoking, hypertension and elevated cholesterol, and it is believed that immune dysfunction also contributes to CVD risk in SLE. In particular, recent studies have shown that abnormalities in both serum lipid profile and the autoantibody and T lymphocyte response to lipids may play a role in development of atherosclerosis. The standard CVD risk calculation algorithms based on traditional risk factors underestimate the risk of developing CVD in patients with SLE. Thus, novel algorithms incorporating new biomarkers such as pro-inflammatory high-density lipoprotein and use of imaging techniques such as carotid ultrasound scanning may become increasingly valuable.

Type: Article
Title: Atherosclerosis in systemic lupus erythematosus
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.berh.2017.09.012
Publisher version: http://dx.doi.org/10.1016/j.berh.2017.09.012
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Atherosclerosis, Autoantibodies, Cardiovascular disease, Invariant natural killer T cells, Lipids, Risk stratification, Systemic lupus erythematosus
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10035122
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