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Longitudinal Analysis Framework of DWI Data for Reconstructing Structural Brain Networks with Application to Multiple Sclerosis

Charalambous, T; Prados Carrasco, F; Tur Gomez, C; Kanber, B; Ourselin, S; Chard, D; Clayden, JD; ... Toosy, A; + view all (2018) Longitudinal Analysis Framework of DWI Data for Reconstructing Structural Brain Networks with Application to Multiple Sclerosis. In: Kaden, E and Grussu, F and Ning, L and Tax, CMW and Veraart, J, (eds.) Computational Diffusion MRI. (pp. pp. 205-218). Springer: Cham, Switzerland.

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Abstract

We consider the problem of reconstructing brain networks in a longitudinal study, where diffusion-weighted and T1-weighted magnetic resonance images have been acquired at multiple time-points for the same subject. We introduce a method for registering diffusion-weighted and structural scans in a subject-specific half-way space and we demonstrate that half-way network metrics are strongly correlated with native network metrics. We also report sufficient agreement between the two techniques in a cohort comprising of healthy controls (n = 12) and multiple sclerosis patients (n = 12). The results remained unaffected when the analyses were evaluated in controls and patients separately. These study findings might be of particular interest in longitudinal structural network studies assessing network changes over time in normal and disease conditions.

Type: Proceedings paper
Title: Longitudinal Analysis Framework of DWI Data for Reconstructing Structural Brain Networks with Application to Multiple Sclerosis
Event: MICCAI Workshop
Location: Quebec, Canada
Dates: 10 September 2017 - 14 September 2017
ISBN-13: 9783319738390
DOI: 10.1007/978-3-319-73839-0_16
Publisher version: https://doi.org/10.1007/978-3-319-73839-0_16
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10033818
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