Curran, S;
Strandkvist, C;
Bathmann, J;
de Gennes, M;
Kabla, A;
Salbreux, G;
Baum, B;
(2017)
Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.
Developmental Cell
10.1016/j.devcel.2017.09.018.
(In press).
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Abstract
Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively studied, less is known about AJ dynamics in other circumstances. Here, we study AJ dynamics in an epithelium that undergoes a gradual increase in packing order, without concomitant large-scale changes in tissue size or shape. We find that neighbor exchange events are driven by stochastic fluctuations in junction length, regulated in part by junctional actomyosin. In this context, the developmental increase of isotropic junctional actomyosin reduces the rate of neighbor exchange, contributing to tissue order. We propose a model in which the local variance in tension between junctions determines whether actomyosin-based forces will inhibit or drive the topological transitions that either refine or deform a tissue.
| Type: | Article |
|---|---|
| Title: | Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.devcel.2017.09.018 |
| Publisher version: | https://doi.org/10.1016/j.devcel.2017.09.018 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY IGO license (http://creativecommons.org/licenses/by/3.0/igo/). |
| Keywords: | epithelia, morphogenesis, Myosin, cadherin, vertex model, neighbor exchange, junction fluctuations, tissue mechanics, tissue refinement, Drosophila |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10029070 |
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