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Multimodal Phase-Based X-Ray Microtomography with Nonmicrofocal Laboratory Sources

Vittoria, FA; Endrizzi, M; Kallon, GK; Hagen, CK; Iacoviello, F; De Coppi, P; Olivo, A; (2017) Multimodal Phase-Based X-Ray Microtomography with Nonmicrofocal Laboratory Sources. Physical Review Applied , 8 (6) , Article 064009. 10.1103/PhysRevApplied.8.064009. Green open access

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Abstract

We present an alternative laboratory implementation of x-ray phase-contrast tomography through a beam-tracking approach. A nonmicrofocal rotating anode source is combined with a high-resolution detector and an absorbing mask to obtain attenuation, phase, and ultra-small-angle scattering tomograms of different specimens. A theoretical model is also presented which justifies the implementation of beam tracking with polychromatic sources and provides quantitative values of attenuation and phase, under the assumption of low sample attenuation. The method is tested on a variety of samples featuring both large and small x-ray attenuation, phase, and scattering signals. The complementarity of the contrast channels can enable subtle distinctions between materials and tissue types, which appear indistinguishable to conventional tomography scanners.

Type: Article
Title: Multimodal Phase-Based X-Ray Microtomography with Nonmicrofocal Laboratory Sources
Open access status: An open access version is available from UCL Discovery
DOI: 10.1103/PhysRevApplied.8.064009
Publisher version: https://doi.org/10.1103/PhysRevApplied.8.064009
Language: English
Additional information: Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/). Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
Keywords: Medical Physics, Optics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10027924
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