Samu, D;
Campbell, KL;
Tsvetanov, KA;
Shafto, MA;
Brayne, C;
Bullmore, ET;
Calder, AC;
... Tyler, LK; + view all
(2017)
Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity.
Nature Communications
, 8
10.1038/ncomms14743.
Preview |
Text
Preserved cognitive functions.pdf - Published Version Download (2MB) | Preview |
Abstract
Healthy ageing has disparate effects on different cognitive domains. The neural basis of these differences, however, is largely unknown. We investigated this question by using Independent Components Analysis to obtain functional brain components from 98 healthy participants aged 23-87 years from the population-based Cam-CAN cohort. Participants performed two cognitive tasks that show age-related decrease (fluid intelligence and object naming) and a syntactic comprehension task that shows age-related preservation. We report that activation of task-positive neural components predicts inter-individual differences in performance in each task across the adult lifespan. Furthermore, only the two tasks that show performance declines with age show age-related decreases in task-positive activation of neural components and decreasing default mode (DM) suppression. Our results suggest that distributed, multi-component brain responsivity supports cognition across the adult lifespan, and the maintenance of this, along with maintained DM deactivation, characterizes successful ageing and may explain differential ageing trajectories across cognitive domains.
| Type: | Article |
|---|---|
| Title: | Preserved cognitive functions with age are determined by domain-dependent shifts in network responsivity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/ncomms14743 |
| Publisher version: | http://dx.doi.org/10.1038/ncomms14743 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Cognitive ageing, Language, Neural ageing |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10026176 |
Archive Staff Only
 |
View Item |
