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Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling

Singh, C; Rihel, J; Prober, DA; (2017) Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling. Current Biology , 27 (24) 3796-3811.e5. 10.1016/j.cub.2017.11.018. Green open access

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Abstract

Sleep is an essential and evolutionarily conserved behavioral state whose regulation remains poorly understood. To identify genes that regulate vertebrate sleep, we recently performed a genetic screen in zebrafish, and here we report the identification of neuropeptide Y (NPY) as both necessary for normal daytime sleep duration and sufficient to promote sleep. We show that overexpression of NPY increases sleep, whereas mutation of npy or ablation of npy-expressing neurons decreases sleep. By analyzing sleep architecture, we show that NPY regulates sleep primarily by modulating the length of wake bouts. To determine how NPY regulates sleep, we tested for interactions with several systems known to regulate sleep, and provide anatomical, molecular, genetic, and pharmacological evidence that NPY promotes sleep by inhibiting noradrenergic signaling. These data establish NPY as an important vertebrate sleep/wake regulator and link NPY signaling to an established arousal-promoting system.

Type: Article
Title: Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cub.2017.11.018
Publisher version: https://doi.org/10.1016/j.cub.2017.11.018
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: sleep, neuropeptide Y, hypothalamus, locus coeruleus, noradrenaline, locomotor activity, arousal, genetics, zebrafish
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10026156
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