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Gene-environment interactions between stress and 5-HTTLPR in depression: A meta-analytic update.

Bleys, D; Luyten, P; Soenens, B; Claes, S; (2017) Gene-environment interactions between stress and 5-HTTLPR in depression: A meta-analytic update. Journal of Affective Disorders , 226 pp. 339-345. 10.1016/j.jad.2017.09.050. Green open access

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Abstract

BACKGROUND: Meta-analyses have yielded contradictory findings concerning the role of 5-HTTLPR in interaction with stress (GxE) in depression. The current meta-analysis investigates if these contradictory findings are a result of differences between studies in methodological approaches towards the assessment of stress and depression. METHODS: After performing a systematic database search (February to December 2016), first, a meta-analysis was used to investigate the total effect size and publication bias. Second, stratified meta-analyses were used to investigate the potential moderating influence of different methodological approaches on heterogeneity of study findings. Third, a meta-regression was used to investigate the combined influence of the methodological approaches on the overall effect size. RESULTS: Results showed a small but significant effect of 5-HTTLPR in interaction with stress in the prediction of depression (OR[95%CI] = 1.18[1.09; 1.28], n = 48 effect sizes from 51 studies, totaling 51,449 participants). There was no evidence of publication bias. Heterogeneity of effect sizes was a result of outliers and not due to different methodological approaches towards the assessment of stress and depression. Yet, there was some evidence that studies adopting a categorical and interview approach to the assessment of stress report higher GxE effects, but further replication of this finding is needed. LIMITATIONS: A large amount of heterogeneity (i.e., 46%) was not explained by the methodological factors included in the study and there was a low response rate of invited studies. CONCLUSIONS: The current meta-analysis provides new evidence for the robustness of the interaction between stress and 5-HTTLPR in depression.

Type: Article
Title: Gene-environment interactions between stress and 5-HTTLPR in depression: A meta-analytic update.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jad.2017.09.050
Publisher version: https://doi.org/10.1016/j.jad.2017.09.050
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: 5-HTTLPR, Depression, Gene-environment interactions, Meta-analysis, Methodology, Stress
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10025759
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