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Flipping the odds of drug development success through human genomics

Hingorani, A; Kuan, V; Finan, C; Kruger, F; Gaulton, A; Chopade, S; Sofat, R; ... Casas, JP; + view all (2017) Flipping the odds of drug development success through human genomics. bioRxiv 10.1101/170142. Green open access

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Abstract

Drug development depends on accurately identifying molecular targets that both play a causal role in a disease and are amenable to pharmacological action by small molecule drugs or bio-therapeutics, such as monoclonal antibodies. Errors in drug target specification contribute to the extremely high rates of drug development failure. Integrating knowledge of genes that encode druggable targets with those that influence susceptibility to common disease has the potential to radically improve the probability of drug development success.

Type: Article
Title: Flipping the odds of drug development success through human genomics
Open access status: An open access version is available from UCL Discovery
DOI: 10.1101/170142
Publisher version: https://doi.org/10.1101/170142
Language: English
Additional information: The copyright holder for this preprint is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
Keywords: Genomics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: https://discovery.ucl.ac.uk/id/eprint/10025188
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