Albarracín, LT;
Patiño, OJ;
Guzman, JD;
Begum, N;
McHugh, TD;
Cuca, LE;
Ávila, MC;
(2017)
Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae).
Revista Colombiana de Quimica
, 46
(3)
pp. 22-27.
10.15446/rev.colomb.quim.v46n3.62963.
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Abstract
Tuberculosis disease causes thousands of deaths worldwide and, currently, the used drugs are either not enough or obsolete for its treatment. Therefore, new compounds that combat this disease are been seek. Thus, the antituberculosis activity of the alkaloids ocoxilonine (1), ocoteine (2), dicentrine (3) and 1,2-methylenedioxy-3,10,11 -tnmetlioxy aporphine (4), isolated from Ocotea discolor wood was evaluated. Their structures were identified by analysis of nuclear magnetic resonance spectroscopic data (NMR ID - 1 H, 13 C, 2 D - COSY, HSQC and HMBC), mass spectra, and comparison with literature data. All the isolated compounds showed antituberculosis activity, with a variation range in the minimum inhibitory concentration between 140 to 310 μM, being ocoteine (2) the most active compound against the virulent strain Mycobacterium tuberculosis H37Rv.
| Type: | Article |
|---|---|
| Title: | Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.15446/rev.colomb.quim.v46n3.62963 |
| Publisher version: | http://dx.doi.org/10.15446/rev.colomb.quim.v46n3.6... |
| Language: | Spanish |
| Additional information: | © 2017, Tsunami Society. All rights reserved. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0. |
| Keywords: | Mycobacterium tuberculosisy, spectroscopic datay Ocoteinq, |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10025104 |
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