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Design and development of low cost polyurethane biopolymer based on castor oil and glycerol for biomedical applications

Tan, A; Polo-Cambronell, B; Provaggi, E; Ardila-Suárez, C; Ramirez-Caballero, G; Baldovino-Medrano, V; Kalaskar, D; (2018) Design and development of low cost polyurethane biopolymer based on castor oil and glycerol for biomedical applications. Biopolymers , 109 (2) , Article e23078. 10.1002/bip.23078. Green open access

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Abstract

In the current study, we present the synthesis of novel low cost bio‐polyurethane compositions with variable mechanical properties based on castor oil and glycerol for biomedical applications. A detailed investigation of the physicochemical properties of the polymer was carried out by using mechanical testing, ATR‐FTIR, and X‐ray photoelectron spectroscopy (XPS). Polymers were also tested in short term in‐vitro cell culture with human mesenchymal stem cells to evaluate their biocompatibility for potential applications as biomaterial. FTIR analysis confirmed the synthesis of castor oil and glycerol based PU polymers. FTIR also showed that the addition of glycerol as co‐polyol increases crosslinking within the polymer backbone hence enhancing the bulk mechanical properties of the polymer. XPS data showed that glycerol incorporation leads to an enrichment of oxidized organic species on the surface of the polymers. Preliminary investigation into in vitro biocompatibility showed that serum protein adsorption can be controlled by varying the glycerol content with polymer backbone. An alamar blue assay looking at the metabolic activity of the cells indicated that castor oil based PU and its variants containing glycerol are non‐toxic to the cells. This study opens an avenue for using low cost bio‐polyurethane based on castor oil and glycerol for biomedical applications.

Type: Article
Title: Design and development of low cost polyurethane biopolymer based on castor oil and glycerol for biomedical applications
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/bip.23078
Publisher version: https://doi.org/10.1002/bip.23078
Language: English
Additional information: Copyright © 2017 The Authors. Biopolymers Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Keywords: biomaterials, biopolymer, castor oil, glycerol, molecular structure analysis, polyurethane
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/10025063
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