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Improved reference tracts for unsupervised brain white matter tractography

Susana Muñoz, M; Bastin, ME; Deary, IJ; Wardlaw, JM; Clayden, JD; (2017) Improved reference tracts for unsupervised brain white matter tractography. In: (Proceedings) MIUA 2017: Medical Image Understanding and Analysis. (pp. pp. 425-435). Springer: Switzerland, Cham. Green open access

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Abstract

Neighbourhood tractography aims to automatically segment equivalent brain white matter tracts from diffusion magnetic resonance imaging (dMRI) data in different subjects by using a “reference tract” as a prior for the shape and length of each tract of interest. In the current work we present a means of improving the technique by using references tracts derived from dMRI data acquired from 80 healthy volunteers aged 25–64 years. The reference tracts were tested on the segmentation of 16 major white matter tracts in 50 healthy older people, aged 71.8 (±0.4) years. We found that data-generated reference tracts improved the automatic white matter tract segmentations compared to results from atlas-generated reference tracts. We also obtained higher percentages of visually acceptable segmented tracts and lower variation in water diffusion parameters using this approach.

Type: Proceedings paper
Title: Improved reference tracts for unsupervised brain white matter tractography
Event: MIUA 2017: Medical Image Understanding and Analysis
ISBN-13: 9783319609638
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-319-60964-5_37
Publisher version: http://doi.org/10.1007/978-3-319-60964-5_37
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: https://discovery.ucl.ac.uk/id/eprint/10024993
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