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Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs

Wu, M; Nern, A; Williamson, WR; Morimoto, MM; Reiser, MB; Card, GM; Rubin, GM; (2016) Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs. eLife , 5 10.7554/eLife.21022. Green open access

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Abstract

Visual projection neurons (VPNs) provide an anatomical connection between early visual processing and higher brain regions. Here we characterize lobula columnar (LC) cells, a class of Drosophila VPNs that project to distinct central brain structures called optic glomeruli. We anatomically describe 22 different LC types and show that, for several types, optogenetic activation in freely moving flies evokes specific behaviors. The activation phenotypes of two LC types closely resemble natural avoidance behaviors triggered by a visual loom. In vivo two-photon calcium imaging reveals that these LC types respond to looming stimuli, while another type does not, but instead responds to the motion of a small object. Activation of LC neurons on only one side of the brain can result in attractive or aversive turning behaviors depending on the cell type. Our results indicate that LC neurons convey information on the presence and location of visual features relevant for specific behaviors.

Type: Article
Title: Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.21022
Publisher version: http://doi.org/10.7554/eLife.21022
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10024819
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