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Core/shell microencapsulation of indomethacin/paracetamol by co-axial electrohydrodynamic atomization

Shams, T; Parhizkar, M; Illangakoon, UE; Orlu, M; Edirisinghe, M; (2017) Core/shell microencapsulation of indomethacin/paracetamol by co-axial electrohydrodynamic atomization. Materials & Design , 136 pp. 204-213. 10.1016/j.matdes.2017.09.052. Green open access

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Abstract

Core/shell microparticles for development of drug delivery systems were prepared using co-axial electrohydrodynamic atomization technique in order to develop fixed dose combined formulations incorporating paracetamol and indomethacin as model drugs. The developed drug delivery systems offered successful co-encapsulation of paracetamol and indomethacin with high drug encapsulation efficiencies of 54% and 69% for paracetamol and indomethacin, respectively. The developed formulations were further characterised with respect to their morphology, drug release profile and possible interactions. In comparison to the release rate of the free indomethacin, the developed formulation resulted in enhanced dissolution rate of indomethacin. This study demonstrates a versatile polymeric platform where multiple drug encapsulation and co-delivery is made possible by utilizing co-axial electrohydrodynamic atomization. The proposed system offered high processing yield of 60–70%, as a single-step platform for preparation of fixed dose formulations for oral drug delivery, particularly in geriatric therapy.

Type: Article
Title: Core/shell microencapsulation of indomethacin/paracetamol by co-axial electrohydrodynamic atomization
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.matdes.2017.09.052
Publisher version: http://doi.org/10.1016/j.matdes.2017.09.052
Language: English
Additional information: © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
Keywords: Electrohydrodynamic atomization; Drug delivery; Oral; Polypharmacy, fixed dose combination
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10024561
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