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Proteomic profiling reveals sub proteomes of the human placenta

Heywood, W; Preece, RL; Pryce, J; Clayton, R; Hallqvist, J; Virasami, A; Mills, K; (2017) Proteomic profiling reveals sub proteomes of the human placenta. Placenta , 59 pp. 69-72. 10.1016/j.placenta.2017.09.014. Green open access

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Abstract

Proteomic characterisation of the placenta has largely been focused on effect of disease, anatomical features or specific cell types. We describe an unbiased proteomic mapping analysis to investigate how the placental proteome changes throughout the organ. A transverse slice of a human placenta was sectioned into 1 × 1cm samples. Sections were analysed using label free proteomics. Analysis revealed two distinct sub-proteomes that did not have anatomical significance. One had a muscular proteome and the other had distinct immunomodulation functions. Chorionic plate enriched proteins highlighted the fetal tissues high energy requirements whilst mechanisms of the decidua observed included modulation of cortisone levels.

Type: Article
Title: Proteomic profiling reveals sub proteomes of the human placenta
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.placenta.2017.09.014
Publisher version: http://doi.org/10.1016/j.placenta.2017.09.014
Language: English
Additional information: © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Proteomics; Placenta; Chorion; Decidua; Trophoblast
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10022842
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