Yirmiya, Nurit;
Charman, Tony;
(2010)
The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics.
Journal of Child Psychology and Psychiatry
, 51
(4)
pp. 432-458.
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Abstract
Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the ‘core’ disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and ‘high risk’ sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. Whilst no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate the early presentation and even ‘prevent’ emergence of the full syndrome.
| Type: | Article |
|---|---|
| Title: | The prodrome of autism: early behavioral and biological signs, regression, peri- and post-natal development and genetics |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | The definitive version is available at www3.interscience.wiley.com |
| UCL classification: | UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10004444 |
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