eprintid: 73893 rev_number: 70 eprint_status: archive userid: 608 dir: disk0/00/07/38/93 datestamp: 2010-10-17 10:03:49 lastmod: 2021-10-09 22:31:31 status_changed: 2014-01-08 11:18:57 type: proceedings_section metadata_visibility: show item_issues_count: 0 creators_name: Patel, S creators_name: Katura, T creators_name: Maki, A creators_name: Tachtsidis, I title: Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F42 keywords: Near-infrared spectroscopy, functional activation note: © 2011 Springer Verlag. The original publication is available at www.springerlink.com abstract: Functional near-infrared optical topography (OT) is used to non-invasively measure the changes in oxygenated and deoxygenated haemoglobin (Delta[HbO(2)], Delta[HHb]) and hence investigate the brain haemodynamic changes, which occur in response to functional activation at specific regions of the cerebral cortex. However, when analysing functional OT data the task-related systemic changes should be taken into account. Here we used an independent component analysis (ICA) method on the OT [HbO(2)] signal, to determine the task-related independent components and then compared them with the systemic measurements (blood pressure, heart rate, scalp blood flow) to assess whether the components are due to systemic noise or neuronal activation. This analysis can therefore extract the true OT haemodynamic neuronal response and hence discriminate between regional activated cortical areas and global haemodynamic changes. date: 2011 publisher: Springer Verlag official_url: http://dx.doi.org/10.1007/978-1-4419-7756-4_7 vfaculties: VENG oa_status: green full_text_type: other language: eng primo: open primo_central: open_green article_type_text: Proceedings Paper verified: verified_manual elements_source: Web of Science elements_id: 125493 doi: 10.1007/978-1-4419-7756-4_7 isbn_13: 9781441977557 lyricists_name: Tachtsidis, Ilias lyricists_id: ITACH19 full_text_status: public series: Advances in Experimental Medicine and Biology publication: OXYGEN TRANSPORT TO TISSUE XXXII volume: 701 place_of_pub: Berlin/ Heidelberg, Germany pagerange: 45 - 51 event_title: 37th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) event_location: Cleveland, OH, US event_dates: 5 - 9 July, 2009 issn: 0065-2598 book_title: Oxygen Transport to Tissue XXXII editors_name: LaManna, JC editors_name: Puchowicz, MA editors_name: Xu, K editors_name: Harrison, DK editors_name: Bruley, DF citation: Patel, S; Katura, T; Maki, A; Tachtsidis, I; (2011) Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis. In: LaManna, JC and Puchowicz, MA and Xu, K and Harrison, DK and Bruley, DF, (eds.) Oxygen Transport to Tissue XXXII. (pp. 45 - 51). Springer Verlag: Berlin/ Heidelberg, Germany. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/73893/1/Patel_et_al_AdvExpMedBiol_2011.pdf