?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Quantification+of+Systemic+Interference+in+Optical+Topography+Data+during+Frontal+Lobe+and+Motor+Cortex+Activation%3A+An+Independent+Component+Analysis&rft.creator=Patel%2C+S&rft.creator=Katura%2C+T&rft.creator=Maki%2C+A&rft.creator=Tachtsidis%2C+I&rft.description=Functional+near-infrared+optical+topography+(OT)+is+used+to+non-invasively+measure+the+changes+in+oxygenated+and+deoxygenated+haemoglobin+(Delta%5BHbO(2)%5D%2C+Delta%5BHHb%5D)+and+hence+investigate+the+brain+haemodynamic+changes%2C+which+occur+in+response+to+functional+activation+at+specific+regions+of+the+cerebral+cortex.+However%2C+when+analysing+functional+OT+data+the+task-related+systemic+changes+should+be+taken+into+account.+Here+we+used+an+independent+component+analysis+(ICA)+method+on+the+OT+%5BHbO(2)%5D+signal%2C+to+determine+the+task-related+independent+components+and+then+compared+them+with+the+systemic+measurements+(blood+pressure%2C+heart+rate%2C+scalp+blood+flow)+to+assess+whether+the+components+are+due+to+systemic+noise+or+neuronal+activation.+This+analysis+can+therefore+extract+the+true+OT+haemodynamic+neuronal+response+and+hence+discriminate+between+regional+activated+cortical+areas+and+global+haemodynamic+changes.&rft.subject=Near-infrared+spectroscopy%2C+functional+activation&rft.publisher=Springer+Verlag&rft.contributor=LaManna%2C+JC&rft.contributor=Puchowicz%2C+MA&rft.contributor=Xu%2C+K&rft.contributor=Harrison%2C+DK&rft.contributor=Bruley%2C+DF&rft.date=2011&rft.type=Proceedings+paper&rft.language=eng&rft.source=+++++In%3A+LaManna%2C+JC+and+Puchowicz%2C+MA+and+Xu%2C+K+and+Harrison%2C+DK+and+Bruley%2C+DF%2C+(eds.)+Oxygen+Transport+to+Tissue+XXXII.++(pp.+45+-+51).++Springer+Verlag%3A+Berlin%2F+Heidelberg%2C+Germany.+(2011)+++++&rft.format=application%2Fpdf&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F73893%2F1%2FPatel_et_al_AdvExpMedBiol_2011.pdf&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F73893%2F&rft.rights=open