eprintid: 5898 rev_number: 24 eprint_status: archive userid: 597 dir: disk0/00/00/58/98 datestamp: 2010-01-07 15:20:14 lastmod: 2015-07-23 09:33:54 status_changed: 2010-01-07 15:20:14 type: article metadata_visibility: show item_issues_count: 0 creators_name: Wittmann, B.C. creators_name: Bunzeck, N. creators_name: Dolan, R.J. creators_name: Duzel, E. creators_id: BWITT39 creators_id: NBUNZ54 creators_id: RJDOL46 creators_id: EDUZE48 title: Anticipation of novelty recruits reward system and hippocampus while promoting recollection ispublished: pub subjects: 26100 subjects: 13100 divisions: F83 divisions: F69 note: Copy made available here for non-commercial use under the terms and conditions set out at http://www.elsevier.com/wps/find/authorsview.authors/supplementalterms1.0 abstract: The dopaminergic midbrain, which comprises the substantia nigra and ventral tegmental area (SN/VTA), plays a central role in reward processing. This region is also activated by novel stimuli, raising the possibility that novelty and reward have shared functional properties. It is currently unclear whether functional aspects of reward processing in the SN/VTA, namely, activation by unexpected rewards and cues that predict reward, also characterise novelty processing. To address this question, we conducted an fMRI experiment during which subjects viewed symbolic cues that predicted either novel or familiar images of scenes with 75% validity. We show that SN/VTA was activated by cues predicting novel images as well as by unexpected novel images that followed familiarity-predictive cues, an 'unexpected novelty' response. The hippocampus, a region implicated in detecting and encoding novel stimuli, showed an anticipatory novelty response but differed from the response profile of SN/VTA in responding at outcome to expected and 'unexpected' novelty. In a behavioural extension of the experiment, recollection increased relative to familiarity when comparing delayed recognition memory for anticipated novel stimuli with unexpected novel stimuli. These data reveal commonalities in SN/VTA responses to anticipating reward and anticipating novel stimuli. We suggest that this anticipatory response codes a motivational exploratory novelty signal that, together with anticipatory activation of the hippocampus, leads to enhanced encoding of novel events. In more general terms, the data suggest that dopaminergic processing of novelty might be important in driving exploration of new environments. date: 2007-10-15 official_url: http://dx.doi.org/10.1016/j.neuroimage.2007.06.038 vfaculties: VFBRS vfaculties: VFBRS oa_status: green language: eng primo: open primo_central: open_green verified: verified_manual doi: 10.1016/j.neuroimage.2007.06.038 lyricists_name: Wittmann, B lyricists_name: Bunzeck, N lyricists_name: Dolan, R lyricists_name: Duzel, E lyricists_id: BWITT39 lyricists_id: NBUNZ54 lyricists_id: RJDOL46 lyricists_id: EDUZE48 full_text_status: public publication: NeuroImage volume: 38 number: 1 pagerange: 194-202 refereed: TRUE issn: 1053-8119 citation: Wittmann, B.C.; Bunzeck, N.; Dolan, R.J.; Duzel, E.; (2007) Anticipation of novelty recruits reward system and hippocampus while promoting recollection. NeuroImage , 38 (1) pp. 194-202. 10.1016/j.neuroimage.2007.06.038 <https://doi.org/10.1016/j.neuroimage.2007.06.038>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/5898/1/5898.pdf