eprintid: 39805
rev_number: 66
eprint_status: archive
userid: 608
dir: disk0/00/03/98/05
datestamp: 2010-10-15 11:43:56
lastmod: 2020-02-12 23:28:32
status_changed: 2010-10-15 11:43:56
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Wilmshurst, JM
creators_name: van Toorn, R
creators_name: Newton, CRJC
title: Withdrawal of parenteral phenobarbitone - Implications for resource-poor countries
ispublished: pub
divisions: UCL
note: Work published in the journal is licensed under a Creative Commons Attribution - Noncommercial 3.0 Unported Works License (CC BY-NC 3.0).
abstract: Parenteral phenobarbitone is an integral part of the management of status epilepticus, especially in the context of resource-poor countries. It is highly effective at controlling seizures. It is safe, cheap, can be given by rapid intravenous push or intramuscular route, boluses can be repeated, and it is recommended as part of the Advanced Paediatric Life Support guidelines. The proposed alternatives lack efficacy, practicality and/or place the child in status epilepticus at risk of respiratory compromise. The impact of the loss of parenteral phenobarbitone would be increased cardiac complications, lack of early seizure control, prolonged seizures resulting in brain damage and systemic complications. Increased numbers of patients will require artificial ventilation in centres without facilities, and centres with facilities will be unable to cope with the load of ventilated patients because of lack of safe transport systems and bed space.
date: 2005-06
official_url: http://www.samj.org.za/index.php/samj/index
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_source: Scopus
elements_id: 69321
lyricists_name: Newton, Charles
lyricists_id: CNEWT91
full_text_status: public
publication: South African Medical Journal
volume: 95
number: 6
pagerange: 422 -423
issn: 0256-9574
citation:        Wilmshurst, JM;    van Toorn, R;    Newton, CRJC;      (2005)    Withdrawal of parenteral phenobarbitone - Implications for resource-poor countries.                   South African Medical Journal , 95  (6)   422 -423.          Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/39805/1/Wilmshurst_Withdrawl_SAMJ_2005.pdf