eprintid: 3668 rev_number: 24 eprint_status: archive userid: 150 dir: disk0/00/00/36/68 datestamp: 2007-06-25 12:00:00 lastmod: 2015-07-23 09:33:33 status_changed: 2008-01-09 13:48:55 type: article metadata_visibility: show creators_name: Turner, M.S. creators_name: Cipolotti, L. creators_name: Yousry, T.A. creators_name: Shallice, T. creators_id: MTURN31 creators_id: LCIPO31 creators_id: TAYOU67 creators_id: TSHAL13 title: Confabulation: damage to a specific inferior medial prefrontal system ispublished: pub subjects: 26100 subjects: 10099 subjects: 13100 divisions: F83 keywords: Confabulation, frontal lobe, executive function, memory, orbitofrontal cortex note: Copyright Masson S.p.A. abstract: Confabulation, the pathological production of false memories, occurs following a variety of aetiologies involving the frontal lobes, and is frequently held to be underpinned by combined memory and executive deficits. However, the critical frontal regions and specific cognitive deficits involved are unclear. Studies in amnesic patients have associated confabulation with damage to the orbital and ventromedial prefrontal cortex. However neuroimaging studies have associated memory control processes which are assumed to underlie confabulation with the right lateral prefrontal cortex. We used a confabulation battery to investigate the occurrence and localisation of confabulation in an unselected series of 38 patients with focal frontal lesions. 12 patients with posterior lesions and 50 healthy controls were included for comparison. Significantly higher levels of confabulation were found in the Frontal group, confirming previous reports. More detailed grouping according to lesion location within the frontal lobe revealed that patients with orbital, medial and left lateral damage confabulated in response to questions probing personal episodic memory. Patients with orbital, medial and right lateral damage confabulated in response to questions probing orientation to time. Performance-led analysis revealed that all patients who produced a total number of confabulations outside the normal range had a lesion affecting either the orbital region or inferior portion of the anterior cingulate. These data provide striking evidence that the critical deficit for confabulation has its anatomical location in the inferior medial frontal lobe. Performance on tests of memory and executive functioning showed considerable variability. Although a degree of memory impairment does seem necessary, performance on traditional executive tests is less helpful in explaining confabulation. date: 2007-06 date_type: submitted official_url: http://dx.doi.org/10.1016/j.cortex.2007.01.002 vfaculties: VFBRS oa_status: green language: eng primo: open primo_central: open_green doi: 10.1016/j.cortex.2007.01.002 lyricists_name: Turner, M lyricists_name: Cipolotti, L lyricists_name: Yousry, T lyricists_name: Shallice, T lyricists_id: MTURN31 lyricists_id: LCIPO31 lyricists_id: TAYOU67 lyricists_id: TSHAL13 full_text_status: public publication: Cortex volume: 44 number: 6 pagerange: 637-648 refereed: TRUE issn: 0010-9452 citation: Turner, M.S.; Cipolotti, L.; Yousry, T.A.; Shallice, T.; (2007) Confabulation: damage to a specific inferior medial prefrontal system. Cortex , 44 (6) pp. 637-648. 10.1016/j.cortex.2007.01.002 <https://doi.org/10.1016/j.cortex.2007.01.002>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/3668/1/3668.pdf