eprintid: 316
rev_number: 17
eprint_status: archive
userid: 1
dir: disk0/00/00/03/16
datestamp: 2005-05-09 12:00:00
lastmod: 2015-07-23 09:33:07
status_changed: 2008-01-09 13:16:18
type: article
metadata_visibility: show
creators_name: Hué, S.
creators_name: Pillay, D.
creators_name: Clewley, J.P.
creators_name: Pybus, O.G.
creators_id: SHUEX44
creators_id: DPILL78
creators_id: 
creators_id: 
title: Genetic analysis reveals the complex structure of HIV-1 transmission within defined risk groups
ispublished: pub
subjects: 3665
abstract: We explored the epidemic history of HIV-1 subtype B in the United Kingdom using
statistical methods that infer the population history of pathogens from sampled gene
sequence data. Phylogenetic analysis of HIV-1 pol gene sequences from Britain showed
at least six large transmission chains, indicating a genetically variable, but
epidemiologically homogeneous, epidemic among men having sex with men. Through
coalescent-based analysis we showed that these chains arose through separate
introductions of subtype B strains into the United Kingdom in the early-to-mid 1980s.
After an initial period of exponential growth, the rate of spread generally slowed in the
early 1990s, which is more likely to correlate with behaviour change than with reduced
infectiousness resulting from highly active antiretroviral therapy. Our results provide new
insights into the complexity of HIV-1 epidemics that must be considered when
developing HIV monitoring and prevention initiatives.
date: 2005-03-22
date_type: published
official_url: http://www.pnas.org/cgi/content/full/102/12/4425
rae2008: 3
oa_status: green
language: eng
primo: open
primo_central: open_green
doi: 10.1073/pnas.0407534102
lyricists_name: Hue, S
lyricists_name: Pillay, D
lyricists_id: SHUEX44
lyricists_id: DPILL78
full_text_status: public
publication: Proceedings of the National Academy of Sciences of the United States of America
volume: 102
number: 12
pagerange: 4425-4429
refereed: TRUE
issn: 1091-6490
citation:        Hué, S.;    Pillay, D.;    Clewley, J.P.;    Pybus, O.G.;      (2005)    Genetic analysis reveals the complex structure of HIV-1 transmission within defined risk groups.                   Proceedings of the National Academy of Sciences of the United States of America , 102  (12)   pp. 4425-4429.    10.1073/pnas.0407534102 <https://doi.org/10.1073/pnas.0407534102>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/316/1/PNAS_Manuscript_Final.pdf