TY  - JOUR
JF  - Journal of Virology
TI  - Modulation of the CD8+-T-cell response by CD4+ CD25+
regulatory T cells in patients with Hepatitis B
virus infection
N2  - CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign
antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of
patients with chronic and resolved hepatitis B virus (HBV) infection. We demonstrated that circulating CD4+
CD25+ T cells modulate the function and expansion of HBV-specific CD8+ cells ex vivo in all patients,
regardless of whether they have chronic or resolved HBV infection. The possible role of CD4+ CD25+ T cells
in the pathogenesis of chronic HBV infection is not supported by these data. However, these results might have
implications for optimizing future immunotherapeutic approaches to HBV treatment.
Y1  - 2005/03//
UR  - http://intl-jvi.asm.org/cgi/content/abstract/79/6/3322
KW  - immunological self-tolerance
KW  -  lamivudine treatment
KW  -  antigen
KW  -  activation
KW  -  disease
KW  -  damage
KW  -  vivo
IS  - 6
SN  - 0022-538x
EP  - 3328
SP  - 3322
A1  - Franzese, O.
A1  - Kennedy, P.T.F.
A1  - Gehring, A.J.
A1  - Gotto, J.
A1  - Williams, R.
A1  - Maini, M.K.
A1  - Bertoletti, A.
AV  - public
ID  - discovery309
VL  - 79
ER  -