eprintid: 21507
rev_number: 49
eprint_status: archive
userid: 608
dir: disk0/00/02/15/07
datestamp: 2010-10-14 16:42:37
lastmod: 2021-11-27 00:07:53
status_changed: 2010-10-14 16:42:37
type: article
metadata_visibility: show
item_issues_count: 0
creators_name: Foltynie, T
creators_name: Matthews, FE
creators_name: Ishihara, L
creators_name: Brayne, C
creators_name: MRC CFAS, The
title: The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: PREVALENCE, ACCURACY, DISORDERS
note: © 2006 Foltynie et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Background: Estimates of the incidence and prevalence of chronic diseases can be made using established cohort studies but these estimates may have lower reliability if based purely on self-reported diagnosis.Methods: The MRC Cognitive Function & Ageing Study ( MRC CFAS) has collected longitudinal data from a population-based random sample of 13004 individuals over the age of 65 years from 5 centres within the UK. Participants were asked at baseline and after a two-year follow-up whether they had received a diagnosis of Parkinson's disease. Our aim was to make estimates of the incidence and prevalence of PD using self-reporting, and then investigate the validity of self-reported diagnosis using other data sources where available, namely death certification and neuropathological examination.Results: The self-reported prevalence of Parkinson's disease ( PD) amongst these individuals increases with age from 0.7% (95% CI 0.5 - 0.9) for 65 - 75, 1.4% ( 95% CI 1.0 - 1.7) for 75 - 85, and 1.6% ( 95% CI 1.0 - 2.3) for 85+ age groups respectively. The overall incidence of self reported PD in this cohort was 200/100,000 per year ( 95% CI 144 - 278). Only 40% of the deceased individuals reporting prevalent PD and 35% of those reporting incident PD had diagnoses of PD recorded on their death certificates. Neuropathological examination of individuals reporting PD also showed typical PD changes in only 40%, with the remainder showing basal ganglia pathologies causing parkinsonism rather than true PD pathology.Conclusion: Self-reporting of PD status may be used as a screening tool to identify patients for epidemiological study, but inevitably identifies a heterogeneous group of movement disorders patients. Within this group, age, male sex, a family history of PD and reduced cigarette smoking appear to act as independent risk factors for self-reported PD.
date: 2006-08-22
publisher: BIOMED CENTRAL LTD
official_url: http://dx.doi.org/10.1186/1471-2377-6-29
vfaculties: VFBRS
oa_status: green
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_batch
elements_source: Web of Science
elements_id: 128765
doi: 10.1186/1471-2377-6-29
language_elements: EN
lyricists_name: Foltynie, Thomas
lyricists_id: TFOLT83
full_text_status: public
publication: BMC Neurology
volume: 6
article_number: 29
issn: 1471-2377
citation:        Foltynie, T;    Matthews, FE;    Ishihara, L;    Brayne, C;    MRC CFAS, The;      (2006)    The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort.                   BMC Neurology , 6     , Article 29.  10.1186/1471-2377-6-29 <https://doi.org/10.1186/1471-2377-6-29>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/21507/1/1471-2377-6-29.pdf