TY  - JOUR
TI  - Treatment response in relation to inflammatory and axonal surrogate marker in multiple sclerosis
AV  - public
Y1  - 2004///
EP  - 283
KW  - S100B
KW  -  neurofilament
KW  -  NfHSMI35 
KW  -  NOx 
KW  -  surrogate marker
KW  -  multiple sclerosis
KW  -  treatment response
N2  - BACKGROUND: This study aimed to investigate if treatment response could retrospectively be related to inflammatory or axonal pathology as measured by plasma surrogate markers. METHODS: In this 1-year observational study 30 multiple sclerosis (MS) patients with relapsing-remitting disease were treated with intramuscular IFNbeta-1a or subcutaneous IFNbeta-1b. Responders and nonresponders were defined according to clinical and magnetic resonance imaging criteria. The control group consisted of 14 healthy subjects. Plasma levels of surrogate markers for inflammation (nitric oxide metabolites (NOx)), astrocytic activation (S100B) and axonal damage (NfH(SM135)) were measured using standard assays. RESULTS: There were 11 nonresponders and 19 responders to IFNbeta treatment. Median S100B levels were elevated in a higher proportion of treatment responders (63%, 42.9 pg/mL) compared to nonresponders (18%, 11.7 pg/mL, P < 0.05, Fisher's exact test) and controls (0%, 2 pg/mL, P < 0.001). Levels of NOx were found to be more frequently elevated in nonresponders (72%, 39 microM) compared to healthy controls (0%, 37 microM, P < 0.05). Levels of NfH(SM135) were more frequently elevated in responders (58%, 300 pg/mL, P < 0.001) and nonresponders (72%, 500 pg/mL, P < 0.001) compared to controls (0%, 4.5 pg/mL). CONCLUSION: Patients with relapsing-remitting MS who had surrogate marker supported evidence for astrocytic activation responded more frequently to treatment with IFNbeta.
ID  - discovery18939
IS  - 3
N1  - © Arnold 2004
VL  - 10
SP  - 281
JF  - Multiple Sclerosis
A1  - Petzold, A.
A1  - Brassat, D.
A1  - Mas, P.
A1  - Rejdak, K.
A1  - Keir, G.
A1  - Giovannoni, G.
A1  - Thompson, E.J.
A1  - Clanet, M.
UR  - http://dx.doi.org/10.1191/1352458504ms1021sr
SN  - 1352-4585
ER  -