<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/18517> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Thesis> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/dc/terms/title> "Imaging the spatial-temporal neuronal dynamics using dynamic causal modelling"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/ontology/bibo/abstract> "Oscillatory brain activity is a ubiquitous feature of neuronal dynamics and\r\nthe synchronous discharge of neurons is believed to facilitate integration both\r\nwithin functionally segregated brain areas and between areas engaged by the same\r\ntask. There is growing interest in investigating the neural oscillatory networks in\r\nvivo. The aims of this thesis are to (1) develop an advanced method, Dynamic\r\nCausal Modelling for Induced Responses (DCM for IR), for modelling the brain\r\nnetwork functions and (2) apply it to exploit the nonlinear coupling in the motor\r\nsystem during hand grips and the functional asymmetries during face perception.\r\nDCM for IR models the time-varying power over a range of\r\nfrequencies of coupled electromagnetic sources. The model parameters encode\r\ncoupling strength among areas and allows the differentiations between linear\r\n(within frequency) and nonlinear (between-frequency) coupling. I applied DCM\r\nfor IR to show that, during hand grips, the nonlinear interactions among neuronal\r\nsources in motor system are essential while intrinsic coupling (within source) is\r\nvery likely to be linear. Furthermore, the normal aging process alters both the\r\nnetwork architecture and the frequency contents in the motor network.\r\nI then use the bilinear form of DCM for IR to model the experimental\r\nmanipulations as the modulatory effects. I use MEG data to demonstrate\r\nfunctional asymmetries between forward and backward connections during face\r\nperception: Specifically, high (gamma) frequencies in higher cortical areas\r\nsuppressed low (alpha) frequencies in lower areas. This finding provides direct\r\nevidence for functional asymmetries that is consistent with anatomical and\r\nphysiological evidence from animal studies. Lastly, I generalize the bilinear form of DCM for IR to dissociate the induced responses from evoked ones in terms of\r\ntheir functional role. The backward modulatory effect is expressed as induced, but\r\nnot evoked responses."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/dc/terms/date> "2009-09" . <https://discovery.ucl.ac.uk/id/document/5668> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> <http://xmlns.com/foaf/0.1/name> "UCL (University College London)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/dc/terms/issuer> <https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> . <https://discovery.ucl.ac.uk/id/org/ext-48e199001bc1163339555c4a94beed31> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-48e199001bc1163339555c4a94beed31> <http://xmlns.com/foaf/0.1/name> "Wellcome Department of Imaging Neuroscience, UCL (University College London)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/org/ext-48e199001bc1163339555c4a94beed31> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/dc/terms/issuer> <https://discovery.ucl.ac.uk/id/org/ext-48e199001bc1163339555c4a94beed31> . <https://discovery.ucl.ac.uk/id/org/ext-a64c3df5861c6582807add1abaadf2af> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/org/ext-48e199001bc1163339555c4a94beed31> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/unpublished> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4424f6f6514767b682618989b5df9755> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/18517#authors> . <https://discovery.ucl.ac.uk/id/eprint/18517#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-4424f6f6514767b682618989b5df9755> . <https://discovery.ucl.ac.uk/id/person/ext-4424f6f6514767b682618989b5df9755> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4424f6f6514767b682618989b5df9755> <http://xmlns.com/foaf/0.1/givenName> "C.-C."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4424f6f6514767b682618989b5df9755> <http://xmlns.com/foaf/0.1/familyName> "Chen"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4424f6f6514767b682618989b5df9755> <http://xmlns.com/foaf/0.1/name> "C.-C. Chen"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ThesisEPrint> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/5668> . <https://discovery.ucl.ac.uk/id/document/5668> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/5668> <http://www.w3.org/2000/01/rdf-schema#label> "Imaging the spatial-temporal neuronal dynamics using dynamic causal modelling (PDF)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/5668> 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<https://discovery.ucl.ac.uk/id/document/81131> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/81131> <http://www.w3.org/2000/01/rdf-schema#label> "Imaging the spatial-temporal neuronal dynamics using dynamic causal modelling (Image (PNG))"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/81131> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/5668> . <https://discovery.ucl.ac.uk/id/document/81131> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/5668> . <https://discovery.ucl.ac.uk/id/document/81131> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/5668> . <https://discovery.ucl.ac.uk/id/document/81131> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/18517/2/preview.png> . <https://discovery.ucl.ac.uk/id/document/81131> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/18517/2/preview.png> . <https://discovery.ucl.ac.uk/id/eprint/18517/2/preview.png> <http://www.w3.org/2000/01/rdf-schema#label> "preview.png"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/106148> . <https://discovery.ucl.ac.uk/id/document/106148> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/106148> <http://www.w3.org/2000/01/rdf-schema#label> "Imaging the spatial-temporal neuronal dynamics using dynamic causal modelling (Other)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/106148> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/5668> . 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"HTML Summary of #18517 \n\nImaging the spatial-temporal neuronal dynamics using dynamic causal modelling\n\n" . <https://discovery.ucl.ac.uk/id/eprint/18517/> <http://purl.org/dc/elements/1.1/format> "text/html" . <https://discovery.ucl.ac.uk/id/eprint/18517/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/18517> . <https://discovery.ucl.ac.uk/id/subject/26100> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/02/skos/core#Concept> . <https://discovery.ucl.ac.uk/id/subject/26100> <http://www.w3.org/2004/02/skos/core#prefLabel> "Wellcome Department of Imaging Neuroscience"@en . <https://discovery.ucl.ac.uk/id/eprint/18517> <http://purl.org/dc/terms/subject> <https://discovery.ucl.ac.uk/id/subject/26100> .