<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/16410> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/title> "VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/abstract> "Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately regulated to result in more complex morphogenetic events, such as tubular sprouting, fusion, and network formation. We show here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts. The tip cells respond to VEGF-A only by guided migration; the proliferative response to VEGF-A occurs in the sprout stalks. These two cellular responses are both mediated by agonistic activity of VEGF-A on VEGF receptor 2. Whereas tip cell migration depends on a gradient of VEGF-A, proliferation is regulated by its concentration. Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/date> "2003-06-23" .
<https://discovery.ucl.ac.uk/id/document/4992> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/volume> "161" .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/issue> "6" .
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<https://discovery.ucl.ac.uk/id/publication/ext-00219525> <http://xmlns.com/foaf/0.1/name> "J CELL BIOL"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-00219525> <http://purl.org/ontology/bibo/issn> "00219525" .
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<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-1ac8e4879a64171a6bf662e919f2fe27> .
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<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-48b43035a8b3c546c74785b39c47e8d4> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bf2a51809a27d106ce096b7e318f8035> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-bf2a51809a27d106ce096b7e318f8035> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4505c6e73dc212863a2a5ed9eaebeb22> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-4505c6e73dc212863a2a5ed9eaebeb22> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-02cd6ec66d3e2176c62885ce5c81a241> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-02cd6ec66d3e2176c62885ce5c81a241> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b83f4ced91055abe383166c108d7908e> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-b83f4ced91055abe383166c108d7908e> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e92a4d0a8e87d2db7cc431e7f32d2e84> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-e92a4d0a8e87d2db7cc431e7f32d2e84> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8ce1cb6dd0c56796ccf1541a4456c7b5> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-8ce1cb6dd0c56796ccf1541a4456c7b5> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d2b311e27034f22aa81d33ba21a84724> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-d2b311e27034f22aa81d33ba21a84724> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a595f00d0483975a2add995874a9e9fb> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-a595f00d0483975a2add995874a9e9fb> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5f7f83bf0ccc98472221d076caa2d06c> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/16410#authors> .
<https://discovery.ucl.ac.uk/id/eprint/16410#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-5f7f83bf0ccc98472221d076caa2d06c> .
<https://discovery.ucl.ac.uk/id/person/ext-48b43035a8b3c546c74785b39c47e8d4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-48b43035a8b3c546c74785b39c47e8d4> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-48b43035a8b3c546c74785b39c47e8d4> <http://xmlns.com/foaf/0.1/familyName> "Golding"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-48b43035a8b3c546c74785b39c47e8d4> <http://xmlns.com/foaf/0.1/name> "M Golding"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a595f00d0483975a2add995874a9e9fb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a595f00d0483975a2add995874a9e9fb> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a595f00d0483975a2add995874a9e9fb> <http://xmlns.com/foaf/0.1/familyName> "Shima"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a595f00d0483975a2add995874a9e9fb> <http://xmlns.com/foaf/0.1/name> "D Shima"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1ac8e4879a64171a6bf662e919f2fe27> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1ac8e4879a64171a6bf662e919f2fe27> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1ac8e4879a64171a6bf662e919f2fe27> <http://xmlns.com/foaf/0.1/familyName> "Gerhardt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1ac8e4879a64171a6bf662e919f2fe27> <http://xmlns.com/foaf/0.1/name> "H Gerhardt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5f7f83bf0ccc98472221d076caa2d06c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5f7f83bf0ccc98472221d076caa2d06c> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5f7f83bf0ccc98472221d076caa2d06c> <http://xmlns.com/foaf/0.1/familyName> "Betsholtz"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5f7f83bf0ccc98472221d076caa2d06c> <http://xmlns.com/foaf/0.1/name> "C Betsholtz"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d2b311e27034f22aa81d33ba21a84724> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d2b311e27034f22aa81d33ba21a84724> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d2b311e27034f22aa81d33ba21a84724> <http://xmlns.com/foaf/0.1/familyName> "Alitalo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d2b311e27034f22aa81d33ba21a84724> <http://xmlns.com/foaf/0.1/name> "K Alitalo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bf2a51809a27d106ce096b7e318f8035> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-bf2a51809a27d106ce096b7e318f8035> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bf2a51809a27d106ce096b7e318f8035> <http://xmlns.com/foaf/0.1/familyName> "Fruttiger"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bf2a51809a27d106ce096b7e318f8035> <http://xmlns.com/foaf/0.1/name> "M Fruttiger"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-02cd6ec66d3e2176c62885ce5c81a241> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-02cd6ec66d3e2176c62885ce5c81a241> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-02cd6ec66d3e2176c62885ce5c81a241> <http://xmlns.com/foaf/0.1/familyName> "Lundkvist"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-02cd6ec66d3e2176c62885ce5c81a241> <http://xmlns.com/foaf/0.1/name> "A Lundkvist"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b83f4ced91055abe383166c108d7908e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b83f4ced91055abe383166c108d7908e> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b83f4ced91055abe383166c108d7908e> <http://xmlns.com/foaf/0.1/familyName> "Abramsson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b83f4ced91055abe383166c108d7908e> <http://xmlns.com/foaf/0.1/name> "A Abramsson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4505c6e73dc212863a2a5ed9eaebeb22> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4505c6e73dc212863a2a5ed9eaebeb22> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4505c6e73dc212863a2a5ed9eaebeb22> <http://xmlns.com/foaf/0.1/familyName> "Ruhrberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4505c6e73dc212863a2a5ed9eaebeb22> <http://xmlns.com/foaf/0.1/name> "C Ruhrberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8ce1cb6dd0c56796ccf1541a4456c7b5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8ce1cb6dd0c56796ccf1541a4456c7b5> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8ce1cb6dd0c56796ccf1541a4456c7b5> <http://xmlns.com/foaf/0.1/familyName> "Mitchell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8ce1cb6dd0c56796ccf1541a4456c7b5> <http://xmlns.com/foaf/0.1/name> "C Mitchell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e92a4d0a8e87d2db7cc431e7f32d2e84> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e92a4d0a8e87d2db7cc431e7f32d2e84> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e92a4d0a8e87d2db7cc431e7f32d2e84> <http://xmlns.com/foaf/0.1/familyName> "Jeltsch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e92a4d0a8e87d2db7cc431e7f32d2e84> <http://xmlns.com/foaf/0.1/name> "M Jeltsch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/16410> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/4992> .
<https://discovery.ucl.ac.uk/id/document/4992> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/4992> <http://www.w3.org/2000/01/rdf-schema#label> "VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia (PDF)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/4992> <http://eprints.org/relation/hasVolatileVersion> <https://discovery.ucl.ac.uk/id/document/80538> .
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<https://discovery.ucl.ac.uk/id/document/4992> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/16410/1/16410.pdf> .
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<https://discovery.ucl.ac.uk/id/eprint/16410/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/16410> .
<https://discovery.ucl.ac.uk/id/subject/26200> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/02/skos/core#Concept> .
<https://discovery.ucl.ac.uk/id/subject/26200> <http://www.w3.org/2004/02/skos/core#prefLabel> "Institute of Ophthalmology"@en .
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