eprintid: 1575089 rev_number: 43 eprint_status: archive userid: 608 dir: disk0/01/57/50/89 datestamp: 2017-09-24 03:43:31 lastmod: 2021-12-06 00:56:28 status_changed: 2017-09-29 10:32:15 type: article metadata_visibility: show creators_name: Lewis, KM creators_name: Ruiz, M creators_name: Goldblatt, P creators_name: Morrison, J creators_name: Porta, D creators_name: Forastiere, F creators_name: Hryhorczuk, D creators_name: Zvinchuk, O creators_name: Saurel-Cubizolles, M-J creators_name: Lioret, S creators_name: Annesi-Maesano, I creators_name: Vrijheid, M creators_name: Torrent, M creators_name: Iniguez, C creators_name: Larranaga, I creators_name: Harskamp-van Ginkel, MW creators_name: Vrijkotte, TGM creators_name: Klanova, J creators_name: Svancara, J creators_name: Barross, H creators_name: Correia, S creators_name: Jarvelin, M-R creators_name: Taanila, A creators_name: Ludvigsson, J creators_name: Faresjo, T creators_name: Marmot, M creators_name: Pikhart, H title: Mother's education and offspring asthma risk in 10 European cohort studies ispublished: pub divisions: UCL divisions: B02 divisions: D12 divisions: G19 divisions: D13 divisions: G25 keywords: Asthma, Children, Cohort studies, Disease risk, Maternal education, Socioeconomic position note: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. abstract: Highly prevalent and typically beginning in childhood, asthma is a burdensome disease, yet the risk factors for this condition are not clarified. To enhance understanding, this study assessed the cohort-specific and pooled risk of maternal education on asthma in children aged 3-8 across 10 European countries. Data on 47,099 children were obtained from prospective birth cohort studies across 10 European countries. We calculated cohort-specific prevalence difference in asthma outcomes using the relative index of inequality (RII) and slope index of inequality (SII). Results from all countries were pooled using random-effects meta-analysis procedures to obtain mean RII and SII scores at the European level. Final models were adjusted for child sex, smoking during pregnancy, parity, mother's age and ethnicity. The higher the score the greater the magnitude of relative (RII, reference 1) and absolute (SII, reference 0) inequity. The pooled RII estimate for asthma risk across all cohorts was 1.46 (95% CI 1.26, 1.71) and the pooled SII estimate was 1.90 (95% CI 0.26, 3.54). Of the countries examined, France, the United Kingdom and the Netherlands had the highest prevalence's of childhood asthma and the largest inequity in asthma risk. Smaller inverse associations were noted for all other countries except Italy, which presented contradictory scores, but with small effect sizes. Tests for heterogeneity yielded significant results for SII scores. Overall, offspring of mothers with a low level of education had an increased relative and absolute risk of asthma compared to offspring of high-educated mothers. date: 2017-09 date_type: published official_url: http://doi.org/10.1007/s10654-017-0309-0 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1423395 doi: 10.1007/s10654-017-0309-0 pii: 10.1007/s10654-017-0309-0 lyricists_name: Lewis, Kate lyricists_name: Marmot, Michael lyricists_name: Morrison, Joana lyricists_name: Pikhart, Hynek lyricists_name: Ruiz, Milagros lyricists_id: KMLEW61 lyricists_id: MGMAR64 lyricists_id: JMORR03 lyricists_id: HPIKH73 lyricists_id: MARUI77 full_text_status: public publication: European Journal of Epidemiology volume: 32 pagerange: 797-805 event_location: Netherlands issn: 1573-7284 citation: Lewis, KM; Ruiz, M; Goldblatt, P; Morrison, J; Porta, D; Forastiere, F; Hryhorczuk, D; ... Pikhart, H; + view all <#> Lewis, KM; Ruiz, M; Goldblatt, P; Morrison, J; Porta, D; Forastiere, F; Hryhorczuk, D; Zvinchuk, O; Saurel-Cubizolles, M-J; Lioret, S; Annesi-Maesano, I; Vrijheid, M; Torrent, M; Iniguez, C; Larranaga, I; Harskamp-van Ginkel, MW; Vrijkotte, TGM; Klanova, J; Svancara, J; Barross, H; Correia, S; Jarvelin, M-R; Taanila, A; Ludvigsson, J; Faresjo, T; Marmot, M; Pikhart, H; - view fewer <#> (2017) Mother's education and offspring asthma risk in 10 European cohort studies. European Journal of Epidemiology , 32 pp. 797-805. 10.1007/s10654-017-0309-0 <https://doi.org/10.1007/s10654-017-0309-0>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1575089/1/Lewis_Lewis2017_Article_MotherSEducationAndOffspringAs.pdf