<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/title> "Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/abstract> "Expression of the Ret receptor tyrosine kinase is a defining feature of enteric neurons. Its importance is underscored by the effects of its mutation in Hirschsprung disease, leading to absence of gut innervation and severe gastrointestinal symptoms. We report a new and physiologically significant site of Ret expression in the intestine: the intestinal epithelium. Experiments in Drosophila indicate that Ret is expressed both by enteric neurons and adult intestinal epithelial progenitors, which require Ret to sustain their proliferation. Mechanistically, Ret is engaged in a positive feedback loop with Wnt/Wingless signalling, modulated by Src and Fak kinases. We find that Ret is also expressed by the developing intestinal epithelium of mice, where its expression is maintained into the adult stage in a subset of enteroendocrine/enterochromaffin cells. Mouse organoid experiments point to an intrinsic role for Ret in promoting epithelial maturation and regulating Wnt signalling. Our findings reveal evolutionary conservation of the positive Ret/Wnt signalling feedback in both developmental and homoeostatic contexts. They also suggest an epithelial contribution to Ret loss-of-function disorders such as Hirschsprung disease."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/date> "2017-09-15" .
<https://discovery.ucl.ac.uk/id/document/476628> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/volume> "36" .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/issue> "18" .
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<https://discovery.ucl.ac.uk/id/publication/ext-14602075> <http://xmlns.com/foaf/0.1/name> "The EMBO Journal"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-14602075> .
<https://discovery.ucl.ac.uk/id/publication/ext-14602075> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:14602075> .
<https://discovery.ucl.ac.uk/id/publication/ext-14602075> <http://purl.org/ontology/bibo/issn> "14602075" .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
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<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-88f1b5220f2457de5b206001c81cf474> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bb280bc14144c091b530030609bc21c1> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-bb280bc14144c091b530030609bc21c1> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-be602eefa16ac09033413dcba75bbafb> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-be602eefa16ac09033413dcba75bbafb> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-396d50bb21fe85cf77b40bc611bdb35c> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-396d50bb21fe85cf77b40bc611bdb35c> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b34fb5bc346e9d78a26e5d2640830d15> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-b34fb5bc346e9d78a26e5d2640830d15> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9b0abff9ab780a065c537fcdd89b37c4> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-9b0abff9ab780a065c537fcdd89b37c4> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-621066907fbe615d341083d78846590f> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-621066907fbe615d341083d78846590f> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7977e7e490df4c3837600e2032cf6303> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-7977e7e490df4c3837600e2032cf6303> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-caced51b589ddcca88e9b671fbda64b7> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-caced51b589ddcca88e9b671fbda64b7> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ef22ece165b7ff3ac6bd3260d931f22d> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-ef22ece165b7ff3ac6bd3260d931f22d> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8848d1608c27c5c34239e09c522f20ab> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-8848d1608c27c5c34239e09c522f20ab> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eba412f0020ffce94c11576b1dadae50> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-eba412f0020ffce94c11576b1dadae50> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4b0d198c223e5b0cf1470e2261446be3> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-4b0d198c223e5b0cf1470e2261446be3> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bfa528cfbb72e0ed0f7d268286cc2fbf> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-bfa528cfbb72e0ed0f7d268286cc2fbf> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-77aad3590a4a6c9f573a13af62bfea26> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-77aad3590a4a6c9f573a13af62bfea26> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-abf16f53608040ec24a3eea3d2424e34> .
<https://discovery.ucl.ac.uk/id/eprint/1574483> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574483#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574483#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-abf16f53608040ec24a3eea3d2424e34> .
<https://discovery.ucl.ac.uk/id/person/ext-ef22ece165b7ff3ac6bd3260d931f22d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ef22ece165b7ff3ac6bd3260d931f22d> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ef22ece165b7ff3ac6bd3260d931f22d> <http://xmlns.com/foaf/0.1/familyName> "Kallijärvi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ef22ece165b7ff3ac6bd3260d931f22d> <http://xmlns.com/foaf/0.1/name> "J Kallijärvi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8848d1608c27c5c34239e09c522f20ab> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8848d1608c27c5c34239e09c522f20ab> <http://xmlns.com/foaf/0.1/givenName> "JA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8848d1608c27c5c34239e09c522f20ab> <http://xmlns.com/foaf/0.1/familyName> "Walker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8848d1608c27c5c34239e09c522f20ab> <http://xmlns.com/foaf/0.1/name> "JA Walker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eba412f0020ffce94c11576b1dadae50> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-eba412f0020ffce94c11576b1dadae50> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eba412f0020ffce94c11576b1dadae50> <http://xmlns.com/foaf/0.1/familyName> "Soba"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eba412f0020ffce94c11576b1dadae50> <http://xmlns.com/foaf/0.1/name> "P Soba"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-396d50bb21fe85cf77b40bc611bdb35c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-396d50bb21fe85cf77b40bc611bdb35c> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-396d50bb21fe85cf77b40bc611bdb35c> <http://xmlns.com/foaf/0.1/familyName> "Konstantinidou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-396d50bb21fe85cf77b40bc611bdb35c> <http://xmlns.com/foaf/0.1/name> "C Konstantinidou"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-caced51b589ddcca88e9b671fbda64b7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-caced51b589ddcca88e9b671fbda64b7> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-caced51b589ddcca88e9b671fbda64b7> <http://xmlns.com/foaf/0.1/familyName> "Natarajan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-caced51b589ddcca88e9b671fbda64b7> <http://xmlns.com/foaf/0.1/name> "D Natarajan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7977e7e490df4c3837600e2032cf6303> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7977e7e490df4c3837600e2032cf6303> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7977e7e490df4c3837600e2032cf6303> <http://xmlns.com/foaf/0.1/familyName> "Hoyer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7977e7e490df4c3837600e2032cf6303> <http://xmlns.com/foaf/0.1/name> "N Hoyer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-621066907fbe615d341083d78846590f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-621066907fbe615d341083d78846590f> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-621066907fbe615d341083d78846590f> <http://xmlns.com/foaf/0.1/familyName> "Carroll"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-621066907fbe615d341083d78846590f> <http://xmlns.com/foaf/0.1/name> "T Carroll"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-88f1b5220f2457de5b206001c81cf474> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-88f1b5220f2457de5b206001c81cf474> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-88f1b5220f2457de5b206001c81cf474> <http://xmlns.com/foaf/0.1/familyName> "Perea"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-88f1b5220f2457de5b206001c81cf474> <http://xmlns.com/foaf/0.1/name> "D Perea"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be602eefa16ac09033413dcba75bbafb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-be602eefa16ac09033413dcba75bbafb> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be602eefa16ac09033413dcba75bbafb> <http://xmlns.com/foaf/0.1/familyName> "Hudry"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-be602eefa16ac09033413dcba75bbafb> <http://xmlns.com/foaf/0.1/name> "B Hudry"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b34fb5bc346e9d78a26e5d2640830d15> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b34fb5bc346e9d78a26e5d2640830d15> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b34fb5bc346e9d78a26e5d2640830d15> <http://xmlns.com/foaf/0.1/familyName> "Milona"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b34fb5bc346e9d78a26e5d2640830d15> <http://xmlns.com/foaf/0.1/name> "A Milona"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-abf16f53608040ec24a3eea3d2424e34> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-abf16f53608040ec24a3eea3d2424e34> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> .
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