<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1574474> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/title> "Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/abstract> "Serum biomarker levels are associated with the risk of complex diseases. Here, we aimed to gain insights into the genetic architecture of biomarker traits which can reflect health status. We performed genome-wide association analyses for twenty serum biomarkers involved in organ function and reproductive health. 9,961 individuals from the UK Household Longitudinal Study were genotyped using the Illumina HumanCoreExome array and variants imputed to the 1000 Genomes Project and UK10K haplotypes. We establish a polygenic heritability for all biomarkers, confirm associations of fifty-four established loci, and identify five novel, replicating associations at genome-wide significance. A low-frequency variant, rs28929474, (beta = 0.04, P = 2 × 10(-10)) was associated with levels of alanine transaminase, an indicator of liver damage. The variant is located in the gene encoding serine protease inhibitor, low levels of which are associated with alpha-1 antitrypsin deficiency which leads to liver disease. We identified novel associations (rs78900934, beta = 0.05, P = 6 × 10(-12); rs2911280, beta = 0.09, P = 6 × 10(-10)) for dihydroepiandrosterone sulphate, a precursor to major sex-hormones, and for glycated haemoglobin (rs12819124, beta = -0.03, P = 4 × 10(-9); rs761772, beta = 0.05, P = 5 × 10(-9)). rs12819124 is nominally associated with risk of type 2 diabetes. Our study offers insights into the genetic architecture of well-known and less well-studied biomarkers."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/date> "2017-09-08" .
<https://discovery.ucl.ac.uk/id/document/476564> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/volume> "7" .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://xmlns.com/foaf/0.1/name> "Scientific Reports"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20452322> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20452322> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://purl.org/ontology/bibo/issn> "20452322" .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-15aa82426b7f2b9dbbec51985345affd> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-15aa82426b7f2b9dbbec51985345affd> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1dfca6e235525ce2494ede8887ceb384> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-1dfca6e235525ce2494ede8887ceb384> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0ba3fd522abf1499e6c4f1e8b68f99d7> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-0ba3fd522abf1499e6c4f1e8b68f99d7> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a56ea2433c6ea45e5aa26bcd15b23637> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-a56ea2433c6ea45e5aa26bcd15b23637> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-407166a226dea1f6172ae879389af1d8> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-407166a226dea1f6172ae879389af1d8> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5f09c12655c51719481e8d1864d3bf17> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-5f09c12655c51719481e8d1864d3bf17> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c0924af1876925e25bc633cb39d82457> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-c0924af1876925e25bc633cb39d82457> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5524f42427cd03f748f845ffbebe22e4> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-5524f42427cd03f748f845ffbebe22e4> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-31c6ea374064a859f10fab2489b8c282> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-31c6ea374064a859f10fab2489b8c282> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2d93107c6ee234ddf34285ccf23bda97> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-2d93107c6ee234ddf34285ccf23bda97> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0bd893231090e8f41747210f48d7c0b5> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-0bd893231090e8f41747210f48d7c0b5> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-67d62ac444d0933f0e7d4e26c1f06443> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-67d62ac444d0933f0e7d4e26c1f06443> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ec234185ce0b5ac42a77c40ef56cf961> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-ec234185ce0b5ac42a77c40ef56cf961> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0a77a410d656ad2f8a3a61772e5c8342> .
<https://discovery.ucl.ac.uk/id/eprint/1574474> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1574474#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1574474#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-0a77a410d656ad2f8a3a61772e5c8342> .
<https://discovery.ucl.ac.uk/id/person/ext-2d93107c6ee234ddf34285ccf23bda97> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2d93107c6ee234ddf34285ccf23bda97> <http://xmlns.com/foaf/0.1/givenName> "JRB"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2d93107c6ee234ddf34285ccf23bda97> <http://xmlns.com/foaf/0.1/familyName> "Perry"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2d93107c6ee234ddf34285ccf23bda97> <http://xmlns.com/foaf/0.1/name> "JRB Perry"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15aa82426b7f2b9dbbec51985345affd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-15aa82426b7f2b9dbbec51985345affd> <http://xmlns.com/foaf/0.1/givenName> "BP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15aa82426b7f2b9dbbec51985345affd> <http://xmlns.com/foaf/0.1/familyName> "Prins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-15aa82426b7f2b9dbbec51985345affd> <http://xmlns.com/foaf/0.1/name> "BP Prins"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a56ea2433c6ea45e5aa26bcd15b23637> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a56ea2433c6ea45e5aa26bcd15b23637> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a56ea2433c6ea45e5aa26bcd15b23637> <http://xmlns.com/foaf/0.1/familyName> "Smart"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a56ea2433c6ea45e5aa26bcd15b23637> <http://xmlns.com/foaf/0.1/name> "M Smart"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c0924af1876925e25bc633cb39d82457> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c0924af1876925e25bc633cb39d82457> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c0924af1876925e25bc633cb39d82457> <http://xmlns.com/foaf/0.1/familyName> "Luan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c0924af1876925e25bc633cb39d82457> <http://xmlns.com/foaf/0.1/name> "J Luan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0bd893231090e8f41747210f48d7c0b5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0bd893231090e8f41747210f48d7c0b5> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0bd893231090e8f41747210f48d7c0b5> <http://xmlns.com/foaf/0.1/familyName> "Langenberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0bd893231090e8f41747210f48d7c0b5> <http://xmlns.com/foaf/0.1/name> "C Langenberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1dfca6e235525ce2494ede8887ceb384> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1dfca6e235525ce2494ede8887ceb384> <http://xmlns.com/foaf/0.1/givenName> "KB"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1dfca6e235525ce2494ede8887ceb384> <http://xmlns.com/foaf/0.1/familyName> "Kuchenbaecker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1dfca6e235525ce2494ede8887ceb384> <http://xmlns.com/foaf/0.1/name> "KB Kuchenbaecker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-31c6ea374064a859f10fab2489b8c282> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-31c6ea374064a859f10fab2489b8c282> <http://xmlns.com/foaf/0.1/givenName> "RA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-31c6ea374064a859f10fab2489b8c282> <http://xmlns.com/foaf/0.1/familyName> "Scott"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-31c6ea374064a859f10fab2489b8c282> <http://xmlns.com/foaf/0.1/name> "RA Scott"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-407166a226dea1f6172ae879389af1d8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-407166a226dea1f6172ae879389af1d8> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-407166a226dea1f6172ae879389af1d8> <http://xmlns.com/foaf/0.1/familyName> "Zabaneh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-407166a226dea1f6172ae879389af1d8> <http://xmlns.com/foaf/0.1/name> "D Zabaneh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5524f42427cd03f748f845ffbebe22e4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5524f42427cd03f748f845ffbebe22e4> <http://xmlns.com/foaf/0.1/givenName> "NJ"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5524f42427cd03f748f845ffbebe22e4> <http://xmlns.com/foaf/0.1/familyName> "Wareham"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5524f42427cd03f748f845ffbebe22e4> <http://xmlns.com/foaf/0.1/name> "NJ Wareham"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-67d62ac444d0933f0e7d4e26c1f06443> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-67d62ac444d0933f0e7d4e26c1f06443> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-67d62ac444d0933f0e7d4e26c1f06443> <http://xmlns.com/foaf/0.1/familyName> "Benzeval"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-67d62ac444d0933f0e7d4e26c1f06443> <http://xmlns.com/foaf/0.1/name> "M Benzeval"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0a77a410d656ad2f8a3a61772e5c8342> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0a77a410d656ad2f8a3a61772e5c8342> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0a77a410d656ad2f8a3a61772e5c8342> <http://xmlns.com/foaf/0.1/familyName> "Zeggini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0a77a410d656ad2f8a3a61772e5c8342> <http://xmlns.com/foaf/0.1/name> "E Zeggini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5f09c12655c51719481e8d1864d3bf17> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5f09c12655c51719481e8d1864d3bf17> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-0ba3fd522abf1499e6c4f1e8b68f99d7> <http://xmlns.com/foaf/0.1/givenName> "Y"^^<http://www.w3.org/2001/XMLSchema#string> .
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