<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1573326> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/title> "Genome-wide profiling of humoral immunity and pathogen genes under selection identifies immune evasion tactics of Chlamydia trachomatis during ocular infection"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/abstract> "The frequency and duration of Chlamydia trachomatis (Ct) ocular infections decrease with age, suggesting development of partial immunity. However, there is a lack of clear correlates of immunity to Ct infection in humans. We screened sera from a cohort of Gambian children followed for six-months against a Ct-proteome microarray. At genome sequence level, we detected signatures of selection from a population of ocular Ct isolates from Guinea-Bissau. Together these approaches allowed us to highlight the focus of humoral responses and hypothesise new modes of pathogen immune evasion. Children who were susceptible to frequent and/or prolonged Ct infection had a less focussed antibody response, including preferential recognition of forty-two antigens. There was evidence of positive and purifying selection across the genome, but little balancing selection. In contrast, most antigens that were associated with susceptibility were under neutral selection. These data suggest an evasion strategy in which Ct presents a large panel of irrelevant antigens to the immune system to block or misdirect protective responses. Development of a focused immune response, possibly induced through vaccination, may be an effective strategy to promote protection to Ct infection."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/date> "2017-08-29" .
<https://discovery.ucl.ac.uk/id/document/470401> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/document/472300> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/volume> "7" .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://xmlns.com/foaf/0.1/name> "Scientific Reports"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20452322> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20452322> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://purl.org/ontology/bibo/issn> "20452322" .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-651a34839153fb3cbfa4ec94aaeb702a> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-651a34839153fb3cbfa4ec94aaeb702a> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2cf85815319495e85315dbca5b29f0f1> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-2cf85815319495e85315dbca5b29f0f1> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0c3a7688f114b030d56c59e17fe2e37f> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-0c3a7688f114b030d56c59e17fe2e37f> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cd94082e5e08a2c223abadbf1baa3465> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-cd94082e5e08a2c223abadbf1baa3465> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-81cd18ffaa449611d4d20d47b93fb1d6> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-81cd18ffaa449611d4d20d47b93fb1d6> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dc7d8e514457e51f7d65215c84ed0b9e> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-dc7d8e514457e51f7d65215c84ed0b9e> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8abc4e84d515880d5ab210cab440c6df> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-8abc4e84d515880d5ab210cab440c6df> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2e68c4fd8b6684f35b9eef322b3d9538> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-2e68c4fd8b6684f35b9eef322b3d9538> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-42b733e8d8e3364b9723097e5dc5b8b6> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-42b733e8d8e3364b9723097e5dc5b8b6> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-743e7bb1b89945e4f6c60c7fa8d602bd> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-743e7bb1b89945e4f6c60c7fa8d602bd> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b310ca6684cdb77d8754aed124cd9c26> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-b310ca6684cdb77d8754aed124cd9c26> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-02285570225035cf54696c50382f3864> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-02285570225035cf54696c50382f3864> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b548127e89b988eabd76f1200e6ece8d> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-b548127e89b988eabd76f1200e6ece8d> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-933bb250b4ef3c8fb405f40c52fca957> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-933bb250b4ef3c8fb405f40c52fca957> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6504fbf9c8761c5ce16d9280a93875b1> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-6504fbf9c8761c5ce16d9280a93875b1> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2fbd9af4b3604ff045c3f0d29000394f> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-2fbd9af4b3604ff045c3f0d29000394f> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9b5476769fc83a398feb371cc310429d> .
<https://discovery.ucl.ac.uk/id/eprint/1573326> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1573326#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1573326#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-9b5476769fc83a398feb371cc310429d> .
<https://discovery.ucl.ac.uk/id/person/ext-b548127e89b988eabd76f1200e6ece8d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b548127e89b988eabd76f1200e6ece8d> <http://xmlns.com/foaf/0.1/givenName> "DCW"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b548127e89b988eabd76f1200e6ece8d> <http://xmlns.com/foaf/0.1/familyName> "Mabey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b548127e89b988eabd76f1200e6ece8d> <http://xmlns.com/foaf/0.1/name> "DCW Mabey"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dc7d8e514457e51f7d65215c84ed0b9e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-dc7d8e514457e51f7d65215c84ed0b9e> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dc7d8e514457e51f7d65215c84ed0b9e> <http://xmlns.com/foaf/0.1/familyName> "Cassama"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dc7d8e514457e51f7d65215c84ed0b9e> <http://xmlns.com/foaf/0.1/name> "E Cassama"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0c3a7688f114b030d56c59e17fe2e37f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0c3a7688f114b030d56c59e17fe2e37f> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0c3a7688f114b030d56c59e17fe2e37f> <http://xmlns.com/foaf/0.1/familyName> "Faal"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0c3a7688f114b030d56c59e17fe2e37f> <http://xmlns.com/foaf/0.1/name> "N Faal"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2cf85815319495e85315dbca5b29f0f1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2cf85815319495e85315dbca5b29f0f1> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2cf85815319495e85315dbca5b29f0f1> <http://xmlns.com/foaf/0.1/familyName> "Teng"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2cf85815319495e85315dbca5b29f0f1> <http://xmlns.com/foaf/0.1/name> "A Teng"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2fbd9af4b3604ff045c3f0d29000394f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2fbd9af4b3604ff045c3f0d29000394f> <http://xmlns.com/foaf/0.1/givenName> "LM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2fbd9af4b3604ff045c3f0d29000394f> <http://xmlns.com/foaf/0.1/familyName> "de la Maza"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2fbd9af4b3604ff045c3f0d29000394f> <http://xmlns.com/foaf/0.1/name> "LM de la Maza"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6504fbf9c8761c5ce16d9280a93875b1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6504fbf9c8761c5ce16d9280a93875b1> <http://xmlns.com/foaf/0.1/givenName> "RD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6504fbf9c8761c5ce16d9280a93875b1> <http://xmlns.com/foaf/0.1/familyName> "Hayward"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6504fbf9c8761c5ce16d9280a93875b1> <http://xmlns.com/foaf/0.1/name> "RD Hayward"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8abc4e84d515880d5ab210cab440c6df> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8abc4e84d515880d5ab210cab440c6df> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8abc4e84d515880d5ab210cab440c6df> <http://xmlns.com/foaf/0.1/familyName> "Nabicassa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8abc4e84d515880d5ab210cab440c6df> <http://xmlns.com/foaf/0.1/name> "M Nabicassa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cd94082e5e08a2c223abadbf1baa3465> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-cd94082e5e08a2c223abadbf1baa3465> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cd94082e5e08a2c223abadbf1baa3465> <http://xmlns.com/foaf/0.1/familyName> "Joof"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cd94082e5e08a2c223abadbf1baa3465> <http://xmlns.com/foaf/0.1/name> "H Joof"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-651a34839153fb3cbfa4ec94aaeb702a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-651a34839153fb3cbfa4ec94aaeb702a> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-651a34839153fb3cbfa4ec94aaeb702a> <http://xmlns.com/foaf/0.1/familyName> "Pickering"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-651a34839153fb3cbfa4ec94aaeb702a> <http://xmlns.com/foaf/0.1/name> "H Pickering"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2e68c4fd8b6684f35b9eef322b3d9538> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2e68c4fd8b6684f35b9eef322b3d9538> <http://xmlns.com/foaf/0.1/givenName> "AR"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-42b733e8d8e3364b9723097e5dc5b8b6> <http://xmlns.com/foaf/0.1/familyName> "Burr"^^<http://www.w3.org/2001/XMLSchema#string> .
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