eprintid: 1571766
rev_number: 39
eprint_status: archive
userid: 608
dir: disk0/01/57/17/66
datestamp: 2017-08-30 11:58:39
lastmod: 2021-10-06 22:53:13
status_changed: 2017-08-30 17:44:45
type: article
metadata_visibility: show
creators_name: Nishimura, T
creators_name: Mizushima, N
title: The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
keywords: ATG9A, RB1CC1, ULK complex, autophagy, phosphatidylinositol synthase
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: In our recent paper, we biochemically analyzed autophagosome-related membranes at the initiation stage of macroautophagy/autophagy using atg knockout (KO) cells and demonstrated that the ULK complex is recruited to 2 distinct membranes: the ER membrane and ATG9A-positive autophagosome precursors. We have also identified phosphatidylinositol synthase (PIS)-enriched ER subdomains as the initiation site of autophagosome formation. Based on these findings, we propose that the ULK complex, the PIS-enriched ER subdomain, and ATG9A vesicles together initiate autophagosome formation.
date: 2017
date_type: published
official_url: http://dx.doi.org/10.1080/15548627.2017.1358344
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1415408
doi: 10.1080/15548627.2017.1358344
lyricists_name: Nishimura, Taki
lyricists_id: TNISH35
actors_name: Nishimura, Taki
actors_id: TNISH35
actors_role: owner
full_text_status: public
publication: Autophagy
volume: 13
number: 10
pagerange: 1795-1796
event_location: United States
issn: 1554-8635
citation:        Nishimura, T;    Mizushima, N;      (2017)    The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains.                   Autophagy , 13  (10)   pp. 1795-1796.    10.1080/15548627.2017.1358344 <https://doi.org/10.1080/15548627.2017.1358344>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1571766/1/Nishimura_ULK_complex_initiates.pdf