%P 1795-1796
%D 2017
%O This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
%T The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains
%X In our recent paper, we biochemically analyzed autophagosome-related membranes at the initiation stage of macroautophagy/autophagy using atg knockout (KO) cells and demonstrated that the ULK complex is recruited to 2 distinct membranes: the ER membrane and ATG9A-positive autophagosome precursors. We have also identified phosphatidylinositol synthase (PIS)-enriched ER subdomains as the initiation site of autophagosome formation. Based on these findings, we propose that the ULK complex, the PIS-enriched ER subdomain, and ATG9A vesicles together initiate autophagosome formation.
%A T Nishimura
%A N Mizushima
%J Autophagy
%N 10
%L discovery1571766
%V 13
%K ATG9A, RB1CC1, ULK complex, autophagy, phosphatidylinositol synthase
%C United States