TY  - JOUR
UR  - http://dx.doi.org/10.1080/15548627.2017.1358344
SN  - 1554-8635
JF  - Autophagy
A1  - Nishimura, T
A1  - Mizushima, N
SP  - 1795
VL  - 13
IS  - 10
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
N2  - In our recent paper, we biochemically analyzed autophagosome-related membranes at the initiation stage of macroautophagy/autophagy using atg knockout (KO) cells and demonstrated that the ULK complex is recruited to 2 distinct membranes: the ER membrane and ATG9A-positive autophagosome precursors. We have also identified phosphatidylinositol synthase (PIS)-enriched ER subdomains as the initiation site of autophagosome formation. Based on these findings, we propose that the ULK complex, the PIS-enriched ER subdomain, and ATG9A vesicles together initiate autophagosome formation.
ID  - discovery1571766
KW  - ATG9A
KW  -  RB1CC1
KW  -  ULK complex
KW  -  autophagy
KW  -  phosphatidylinositol synthase
TI  - The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains
AV  - public
Y1  - 2017///
EP  - 1796
ER  -