%0 Journal Article
%@ 1554-8635
%A Nishimura, T
%A Mizushima, N
%D 2017
%F discovery:1571766
%J Autophagy
%K ATG9A, RB1CC1, ULK complex, autophagy, phosphatidylinositol synthase
%N 10
%P 1795-1796
%T The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains
%U https://discovery.ucl.ac.uk/id/eprint/1571766/
%V 13
%X In our recent paper, we biochemically analyzed autophagosome-related membranes at the initiation stage of macroautophagy/autophagy using atg knockout (KO) cells and demonstrated that the ULK complex is recruited to 2 distinct membranes: the ER membrane and ATG9A-positive autophagosome precursors. We have also identified phosphatidylinositol synthase (PIS)-enriched ER subdomains as the initiation site of autophagosome formation. Based on these findings, we propose that the ULK complex, the PIS-enriched ER subdomain, and ATG9A vesicles together initiate autophagosome formation.
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.