@article{discovery1571766,
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
          volume = {13},
          number = {10},
         journal = {Autophagy},
            year = {2017},
           title = {The ULK complex initiates autophagosome formation at phosphatidylinositol synthase-enriched ER subdomains},
           pages = {1795--1796},
        keywords = {ATG9A, RB1CC1, ULK complex, autophagy, phosphatidylinositol synthase},
             url = {http://dx.doi.org/10.1080/15548627.2017.1358344},
            issn = {1554-8635},
        abstract = {In our recent paper, we biochemically analyzed autophagosome-related membranes at the initiation stage of macroautophagy/autophagy using atg knockout (KO) cells and demonstrated that the ULK complex is recruited to 2 distinct membranes: the ER membrane and ATG9A-positive autophagosome precursors. We have also identified phosphatidylinositol synthase (PIS)-enriched ER subdomains as the initiation site of autophagosome formation. Based on these findings, we propose that the ULK complex, the PIS-enriched ER subdomain, and ATG9A vesicles together initiate autophagosome formation.},
          author = {Nishimura, T and Mizushima, N}
}