?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Exploiting+statistical+independence+for+quantitative+photoacoustic+tomography&rft.creator=An%2C+L&rft.creator=Saratoon%2C+T&rft.creator=Fonseca%2C+M&rft.creator=Ellwood%2C+R&rft.creator=Cox%2C+B&rft.description=To+unlock+the+full+capability+of+photoacoustic+tomography+as+a+quantitative%2C+high+resolution%2C+molecular+imaging+modality%2C+the+problem+of+quantitative+photoacoustic+tomography+must+be+solved.+The+aim+in+this+is+to+extract+clinically+relevant+functional+information+from+photoacoustic+images+by+finding+the+concentrations+of+the+chromophores+in+the+tissue.+This+is+a+challenging+task+due+to+the+effect+of+the+unknown+but+spatially+and+spectrally+varying+light+fluence+within+the+tissue.+Many+inversion+schemes+that+include+a+model+of+the+fluence+have+been+proposed%2C+but+these+have+yet+to+make+an+impact+in+pre-clinical+or+clinical+imaging.+In+this+study%2C+the+statistical+independence+of+the+chromophore's+distributions+is+proposed+as+a+means+of+improving+the+robustness+and+hence+the+usefulness+of+the+model-based+inversion+methods.+This+was+achieved+by+minimising+the+mutual+information+between+the+estimated+chromophore+distributions+in+addition+to+the+least+squares+data+error+within+a+gradient-based+optimisation+scheme.+By+applying+the+proposed+inversion+scheme+to+simulated+multiwavelength+photoacoustic+images%2C+it+was+shown+that+more+accurate+estimates+for+the+concentrations+of+independent+chromophores+could+be+obtained+in+the+presence+of+errors+in+the+model+parameters.&rft.subject=Science+%26+Technology%2C+Physical+Sciences%2C+Life+Sciences+%26+Biomedicine%2C+Optics%2C+Radiology%2C+Nuclear+Medicine+%26+Medical+Imaging%2C+Quantitative+photoacoustic+tomography%2C+statistical+independence%2C+model-based+inversion%2C+mutual+information%2C+gradient-based+minimisation%2C+experimental+uncertainty%2C+multiwavelength%2C+RANGE&rft.publisher=Society+of+Photo-Optical+Instrumentation+Engineers+(SPIE)&rft.contributor=Oraevsky%2C+AA&rft.contributor=Wang%2C+LV&rft.date=2017-03-23&rft.type=Proceedings+paper&rft.publisher=Conference+on+Photons+Plus+Ultrasound+-+Imaging+and+Sensing&rft.language=eng&rft.source=+++++In%3A+Oraevsky%2C+AA+and+Wang%2C+LV%2C+(eds.)+Photons+Plus+Ultrasound%3A+Imaging+and+Sensing+2017.++(pp.+pp.+10064191-10064197).++Society+of+Photo-Optical+Instrumentation+Engineers+(SPIE)+(2017)+++++&rft.format=text&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F1570831%2F1%2FEllwood_1006419.pdf&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F1570831%2F&rft.rights=open