<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1569762> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/title> "Re-defining the stress cortisol response to surgery"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Cortisol levels rise with the physiological stress of surgery. Previous studies have used older, less-specific assays, have not differentiated by severity, or only studied procedures of a defined type. The aim of this study was to examine this phenomenon in surgeries of varying severity using a widely used cortisol immunoassay. METHODS: Euadrenal patients undergoing elective surgery were enrolled prospectively. Serum samples were taken at 8 am on surgical day, induction and 1 hr, 2 hr, 4 hr and 8 hr after. Subsequent samples were taken daily at 8 am until post-operative day 5 or hospital discharge. Total cortisol was measured using an Abbott Architect immunoassay, and cortisol binding globulin (CBG) using a radioimmunoassay. Surgical severity was classified by POSSUM operative severity score. RESULTS: 93 patients underwent surgery: Major/Major+ (n=37), Moderate (n=33), and Minor (n=23). Peak cortisol positively correlated to severity: Major/Major+ median 680 [range 375-1452], Moderate 581 [270-1009], and Minor 574 [272-1066] nmol/L (Kruskal-Wallis test, P=0.0031). CBG fell by 23%; the magnitude of the drop positively correlated to severity. CONCLUSIONS: The range in baseline and peak cortisol response to surgery is wide, and peak cortisol levels lower than previously appreciated. Improvements in surgery, anaesthetic techniques, and cortisol assays might explain our observed lower peak cortisols. The criteria for the dynamic testing of cortisol response may need to be reduced to take account of these factors. Our data also support a lower-dose, stratified approach to dosing of steroid replacement in hypoadrenal patients, to minimise the deleterious effects of over-replacement."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/date> "2017-11" .
<https://discovery.ucl.ac.uk/id/document/456428> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/document/456433> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/document/456441> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/document/456446> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/document/456453> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/volume> "87" .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/issue> "5" .
<https://discovery.ucl.ac.uk/id/publication/ext-13652265> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-13652265> <http://xmlns.com/foaf/0.1/name> "Clinical Endocrinology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-13652265> .
<https://discovery.ucl.ac.uk/id/publication/ext-13652265> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:13652265> .
<https://discovery.ucl.ac.uk/id/publication/ext-13652265> <http://purl.org/ontology/bibo/issn> "13652265" .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-722c9a83d1347ae835b7fa6b11e6e87a> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-722c9a83d1347ae835b7fa6b11e6e87a> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5d5eff7e059639d0ea70e07889eef8b0> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-5d5eff7e059639d0ea70e07889eef8b0> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fe3c3da395609314fdeeef578207b68e> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-fe3c3da395609314fdeeef578207b68e> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-220a8317334ad159c1321ee67c04d7ac> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-220a8317334ad159c1321ee67c04d7ac> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4e04decc15bd461846ce9d9d6fe8875e> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-4e04decc15bd461846ce9d9d6fe8875e> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-baed2293bf9954ed6630fa39f5643a03> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-baed2293bf9954ed6630fa39f5643a03> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5060c5c540ad15764cecb5006912dc01> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-5060c5c540ad15764cecb5006912dc01> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dd6983707202cc3b9dee3a429e35504a> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-dd6983707202cc3b9dee3a429e35504a> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a89b2b298281d4ad23d72dfeb5aad116> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-a89b2b298281d4ad23d72dfeb5aad116> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-30299a775fd2013c3e6c9121ebd32461> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-30299a775fd2013c3e6c9121ebd32461> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-beca62634630b266709427d2a803447a> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-beca62634630b266709427d2a803447a> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-81e6b26a43931463897ca9c37aeeb23e> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-81e6b26a43931463897ca9c37aeeb23e> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9ac4f4ba5e90e9c731b1b445e5f4ef09> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-9ac4f4ba5e90e9c731b1b445e5f4ef09> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-73d91c17e7ae98711ad3517cf23a573c> .
<https://discovery.ucl.ac.uk/id/eprint/1569762> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569762#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569762#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-73d91c17e7ae98711ad3517cf23a573c> .
<https://discovery.ucl.ac.uk/id/person/ext-5d5eff7e059639d0ea70e07889eef8b0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5d5eff7e059639d0ea70e07889eef8b0> <http://xmlns.com/foaf/0.1/givenName> "PR"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5d5eff7e059639d0ea70e07889eef8b0> <http://xmlns.com/foaf/0.1/familyName> "Boshier"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5d5eff7e059639d0ea70e07889eef8b0> <http://xmlns.com/foaf/0.1/name> "PR Boshier"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-beca62634630b266709427d2a803447a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-beca62634630b266709427d2a803447a> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-beca62634630b266709427d2a803447a> <http://xmlns.com/foaf/0.1/familyName> "Spalding"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-beca62634630b266709427d2a803447a> <http://xmlns.com/foaf/0.1/name> "D Spalding"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-220a8317334ad159c1321ee67c04d7ac> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-220a8317334ad159c1321ee67c04d7ac> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-220a8317334ad159c1321ee67c04d7ac> <http://xmlns.com/foaf/0.1/familyName> "Tharakan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-220a8317334ad159c1321ee67c04d7ac> <http://xmlns.com/foaf/0.1/name> "G Tharakan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-baed2293bf9954ed6630fa39f5643a03> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-baed2293bf9954ed6630fa39f5643a03> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-baed2293bf9954ed6630fa39f5643a03> <http://xmlns.com/foaf/0.1/familyName> "Hill"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-baed2293bf9954ed6630fa39f5643a03> <http://xmlns.com/foaf/0.1/name> "N Hill"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5060c5c540ad15764cecb5006912dc01> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5060c5c540ad15764cecb5006912dc01> <http://xmlns.com/foaf/0.1/givenName> "EL"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5060c5c540ad15764cecb5006912dc01> <http://xmlns.com/foaf/0.1/familyName> "Williams"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5060c5c540ad15764cecb5006912dc01> <http://xmlns.com/foaf/0.1/name> "EL Williams"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-81e6b26a43931463897ca9c37aeeb23e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-81e6b26a43931463897ca9c37aeeb23e> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-81e6b26a43931463897ca9c37aeeb23e> <http://xmlns.com/foaf/0.1/familyName> "Palazzo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-81e6b26a43931463897ca9c37aeeb23e> <http://xmlns.com/foaf/0.1/name> "F Palazzo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a89b2b298281d4ad23d72dfeb5aad116> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a89b2b298281d4ad23d72dfeb5aad116> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a89b2b298281d4ad23d72dfeb5aad116> <http://xmlns.com/foaf/0.1/familyName> "Tolley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a89b2b298281d4ad23d72dfeb5aad116> <http://xmlns.com/foaf/0.1/name> "N Tolley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ac4f4ba5e90e9c731b1b445e5f4ef09> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9ac4f4ba5e90e9c731b1b445e5f4ef09> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ac4f4ba5e90e9c731b1b445e5f4ef09> <http://xmlns.com/foaf/0.1/familyName> "Meeran"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9ac4f4ba5e90e9c731b1b445e5f4ef09> <http://xmlns.com/foaf/0.1/name> "K Meeran"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dd6983707202cc3b9dee3a429e35504a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-dd6983707202cc3b9dee3a429e35504a> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dd6983707202cc3b9dee3a429e35504a> <http://xmlns.com/foaf/0.1/familyName> "Moorthy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dd6983707202cc3b9dee3a429e35504a> <http://xmlns.com/foaf/0.1/name> "K Moorthy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fe3c3da395609314fdeeef578207b68e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fe3c3da395609314fdeeef578207b68e> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fe3c3da395609314fdeeef578207b68e> <http://xmlns.com/foaf/0.1/familyName> "Freethy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fe3c3da395609314fdeeef578207b68e> <http://xmlns.com/foaf/0.1/name> "A Freethy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-73d91c17e7ae98711ad3517cf23a573c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-73d91c17e7ae98711ad3517cf23a573c> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-73d91c17e7ae98711ad3517cf23a573c> <http://xmlns.com/foaf/0.1/familyName> "Tan"^^<http://www.w3.org/2001/XMLSchema#string> .
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