<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/title> "Chemotactic synthetic vesicles: Design and applications in blood-brain barrier crossing"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/abstract> "In recent years, scientists have created artificial microscopic and nanoscopic self-propelling particles, often referred to as nano- or microswimmers, capable of mimicking biological locomotion and taxis. This active diffusion enables the engineering of complex operations that so far have not been possible at the micro- and nanoscale. One of the most promising tasks is the ability to engineer nanocarriers that can autonomously navigate within tissues and organs, accessing nearly every site of the human body guided by endogenous chemical gradients. We report a fully synthetic, organic, nanoscopic system that exhibits attractive chemotaxis driven by enzymatic conversion of glucose. We achieve this by encapsulating glucose oxidase alone or in combination with catalase into nanoscopic and biocompatible asymmetric polymer vesicles (known as polymersomes). We show that these vesicles self-propel in response to an external gradient of glucose by inducing a slip velocity on their surface, which makes them move in an extremely sensitive way toward higher-concentration regions. We finally demonstrate that the chemotactic behavior of these nanoswimmers, in combination with LRP-1 (low-density lipoprotein receptor-related protein 1) targeting, enables a fourfold increase in penetration to the brain compared to nonchemotactic systems."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/date> "2017-08" .
<https://discovery.ucl.ac.uk/id/document/451380> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/volume> "3" .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/issue> "8" .
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<https://discovery.ucl.ac.uk/id/publication/ext-23752548> <http://xmlns.com/foaf/0.1/name> "Science Advances"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-23752548> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:23752548> .
<https://discovery.ucl.ac.uk/id/publication/ext-23752548> <http://purl.org/ontology/bibo/issn> "23752548" .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
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<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1d98610d398cdcfa0e4f90b40d4d8f6c> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-1d98610d398cdcfa0e4f90b40d4d8f6c> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fdd27e7fee60e184acefc0682dd84cae> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-fdd27e7fee60e184acefc0682dd84cae> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-27c3132f25bc53c86d284df046f276bd> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-27c3132f25bc53c86d284df046f276bd> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4311e2ef19b99a83172b5a66843c734f> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-4311e2ef19b99a83172b5a66843c734f> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-30b6b8410647f3d9ba84877220e0c6a5> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-30b6b8410647f3d9ba84877220e0c6a5> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2032cd9eb05ef08fddb48f70a370a838> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-2032cd9eb05ef08fddb48f70a370a838> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c7aab4003f0b77d51b39b80fff1bc60b> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-c7aab4003f0b77d51b39b80fff1bc60b> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bbe3c687b04ac9f46c2f1ffe3ece96f0> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-bbe3c687b04ac9f46c2f1ffe3ece96f0> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c15bd933fbdd857b8062e27ae6cb4eab> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-c15bd933fbdd857b8062e27ae6cb4eab> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-564650a41bbc0802f0d57e609676762a> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-564650a41bbc0802f0d57e609676762a> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7b87c5b7d61afa38ffe9ef88571de8bb> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1569554#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1569554#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-7b87c5b7d61afa38ffe9ef88571de8bb> .
<https://discovery.ucl.ac.uk/id/person/ext-fdd27e7fee60e184acefc0682dd84cae> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fdd27e7fee60e184acefc0682dd84cae> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fdd27e7fee60e184acefc0682dd84cae> <http://xmlns.com/foaf/0.1/familyName> "Cecchin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fdd27e7fee60e184acefc0682dd84cae> <http://xmlns.com/foaf/0.1/name> "D Cecchin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-564650a41bbc0802f0d57e609676762a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-564650a41bbc0802f0d57e609676762a> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-564650a41bbc0802f0d57e609676762a> <http://xmlns.com/foaf/0.1/familyName> "Volpe"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-564650a41bbc0802f0d57e609676762a> <http://xmlns.com/foaf/0.1/name> "G Volpe"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2032cd9eb05ef08fddb48f70a370a838> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2032cd9eb05ef08fddb48f70a370a838> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2032cd9eb05ef08fddb48f70a370a838> <http://xmlns.com/foaf/0.1/familyName> "Fullstone"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2032cd9eb05ef08fddb48f70a370a838> <http://xmlns.com/foaf/0.1/name> "G Fullstone"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c15bd933fbdd857b8062e27ae6cb4eab> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c15bd933fbdd857b8062e27ae6cb4eab> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c15bd933fbdd857b8062e27ae6cb4eab> <http://xmlns.com/foaf/0.1/familyName> "Preston"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c15bd933fbdd857b8062e27ae6cb4eab> <http://xmlns.com/foaf/0.1/name> "J Preston"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1d98610d398cdcfa0e4f90b40d4d8f6c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1d98610d398cdcfa0e4f90b40d4d8f6c> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1d98610d398cdcfa0e4f90b40d4d8f6c> <http://xmlns.com/foaf/0.1/familyName> "Contini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1d98610d398cdcfa0e4f90b40d4d8f6c> <http://xmlns.com/foaf/0.1/name> "C Contini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c7aab4003f0b77d51b39b80fff1bc60b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c7aab4003f0b77d51b39b80fff1bc60b> <http://xmlns.com/foaf/0.1/givenName> "X"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c7aab4003f0b77d51b39b80fff1bc60b> <http://xmlns.com/foaf/0.1/familyName> "Tian"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c7aab4003f0b77d51b39b80fff1bc60b> <http://xmlns.com/foaf/0.1/name> "X Tian"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-27c3132f25bc53c86d284df046f276bd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-27c3132f25bc53c86d284df046f276bd> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-27c3132f25bc53c86d284df046f276bd> <http://xmlns.com/foaf/0.1/familyName> "Nyberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-27c3132f25bc53c86d284df046f276bd> <http://xmlns.com/foaf/0.1/name> "S Nyberg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4311e2ef19b99a83172b5a66843c734f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4311e2ef19b99a83172b5a66843c734f> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4311e2ef19b99a83172b5a66843c734f> <http://xmlns.com/foaf/0.1/familyName> "Ruiz-Perez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4311e2ef19b99a83172b5a66843c734f> <http://xmlns.com/foaf/0.1/name> "L Ruiz-Perez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bbe3c687b04ac9f46c2f1ffe3ece96f0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-bbe3c687b04ac9f46c2f1ffe3ece96f0> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bbe3c687b04ac9f46c2f1ffe3ece96f0> <http://xmlns.com/foaf/0.1/familyName> "Azizi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bbe3c687b04ac9f46c2f1ffe3ece96f0> <http://xmlns.com/foaf/0.1/name> "J Azizi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-30b6b8410647f3d9ba84877220e0c6a5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-30b6b8410647f3d9ba84877220e0c6a5> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-30b6b8410647f3d9ba84877220e0c6a5> <http://xmlns.com/foaf/0.1/familyName> "Gaitzsch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-30b6b8410647f3d9ba84877220e0c6a5> <http://xmlns.com/foaf/0.1/name> "J Gaitzsch"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7b87c5b7d61afa38ffe9ef88571de8bb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7b87c5b7d61afa38ffe9ef88571de8bb> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7b87c5b7d61afa38ffe9ef88571de8bb> <http://xmlns.com/foaf/0.1/familyName> "Battaglia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7b87c5b7d61afa38ffe9ef88571de8bb> <http://xmlns.com/foaf/0.1/name> "G Battaglia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5559973ac0dd4dc99744cc2c3d694140> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5559973ac0dd4dc99744cc2c3d694140> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5559973ac0dd4dc99744cc2c3d694140> <http://xmlns.com/foaf/0.1/familyName> "Joseph"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5559973ac0dd4dc99744cc2c3d694140> <http://xmlns.com/foaf/0.1/name> "A Joseph"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1569554> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
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