eprintid: 1569389
rev_number: 45
eprint_status: archive
userid: 608
dir: disk0/01/56/93/89
datestamp: 2017-08-09 14:29:03
lastmod: 2020-02-13 01:05:29
status_changed: 2017-09-14 10:45:59
type: article
metadata_visibility: show
creators_name: Murdan, S
creators_name: Bari, A
creators_name: Ahmed, S
creators_name: Hossin, B
creators_name: Kerai, L
title: Nail lacquer films' surface energies and in vitro water-resistance and adhesion do not predict their in vivo residence
ispublished: pub
divisions: UCL
divisions: A01
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: nail, laquer, in-vitro in-vivo correlations
note: Open Access under the Creative Commons CC BY 4.0 Licence (https://creativecommons.org/licenses/by/4.0/).
abstract: The in vivo residence of nail lacquers (which are ideal topical drug carriers for the treatment of nail diseases) determines their frequency of application, and is thereby expected to influence patient adherence and success of treatment. Thus in vitro measurements to indicate lacquers’ in vivo residence are routinely conducted during formulation development. However the literature on in vitro-in vivo correlations is severely limited. Thus, the aim of the work discussed in this paper was to investigate correlations between in vivo residence and in vitro film resistance to water, in vitro film adhesion and surface energy of lacquer films. In vivo measurements were conducted on fingernails in six volunteers. Seven commercially available nail lacquers were tested in commonly-used measurements. Correlations between in vivo residence and in vitro water resistance and adhesion were found to be extremely poor. The surface energies of the lacquer films (which were between 33 and 39 mJ/m2) were also not predictive of in vivo residence. High density polyethylene (HDPE) sheet – whose surface energy was determined to be similar to that of the human nailplate – was found to be a suitable model for the nailplate (when investigating surface energy) and was used in a number of experiments.
date: 2017
date_type: published
official_url: http://doi.org/10.5920/bjpharm.2017.03
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1410581
doi: 10.5920/bjpharm.2017.03
lyricists_name: Murdan, Sudaxshina
lyricists_id: SMURD86
actors_name: Murdan, Sudaxshina
actors_name: Flynn, Bernadette
actors_id: SMURD86
actors_id: BFFLY94
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: British Journal of Pharmacy
volume: 2
number: 1
article_number: 3
issn: 2058-8356
citation:        Murdan, S;    Bari, A;    Ahmed, S;    Hossin, B;    Kerai, L;      (2017)    Nail lacquer films' surface energies and in vitro water-resistance and adhesion do not predict their in vivo residence.                   British Journal of Pharmacy , 2  (1)    , Article 3.  10.5920/bjpharm.2017.03 <https://doi.org/10.5920/bjpharm.2017.03>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1569389/1/Murdan_Nail_lacquer_films_VoR.pdf