eprintid: 1566608
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/01/56/66/08
datestamp: 2017-07-25 09:11:54
lastmod: 2021-12-06 00:58:21
status_changed: 2017-07-25 09:11:54
type: article
metadata_visibility: show
creators_name: Sherratt, FC
creators_name: Eaton, SJ
creators_name: Walker, E
creators_name: Beasant, L
creators_name: Blazeby, JM
creators_name: Young, B
creators_name: Crawley, E
creators_name: Wood, W
creators_name: Hall, NJ
title: Development of a core outcome set to determine the overall treatment success of acute uncomplicated appendicitis in children: a study protocol
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G22
note: Copyright © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
abstract: INTRODUCTION: In recent years, there has been growing interest in alternatives to appendicectomy. In particular, non-operative treatment of appendicitis, with antibiotics alone, has been proposed as a potential treatment. A small number of randomised controlled trials (RCTs) in adults and, more recently, children suggest that antibiotic treatment may be a valid alternative to appendicectomy. However, there is currently insufficient data to justify its widespread use. Prior to performing further efficacy studies of the treatment of appendicitis in children, it is imperative to identify the most relevant outcome measures for inclusion in the design of comparative studies. This is of particular importance when evaluating a novel treatment approach since the outcomes of importance may differ from those commonly reported with traditional therapies.

A review of the relevant literature and electronic resources failed to identify a core outcome set (COS) for children with appendicitis. We aim to define a COS for the measurement of treatment interventions in children (<18 years) with acute appendicitis.
METHODS AND ANALYSIS: This project will entail: (1) a systematic review to identify previously reported acute uncomplicated appendicitis treatment outcomes; (2) assembly of stakeholder panels (paediatric and adult surgeons, patients and parents); (3) a three-stage Delphi process; and (4) a final consensus meeting to complete the COS.

ETHICS AND REGISTRATION: COS development is part of CONservative TReatment of Appendicitis in Children - a randomised controlled Trial (Feasibility) (CONTRACT) study, for which full ethical approval for CONTRACT has been granted. The COS development study is registered with the COMET Initiative in May 2017 (http://www.comet-initiative.org/studies/details/987).
date: 2017-08
date_type: published
official_url: http://dx.doi.org/10.1136/bmjpo-2017-000151
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1405667
doi: 10.1136/bmjpo-2017-000151
lyricists_name: Eaton, Simon
lyricists_id: SEATO65
actors_name: Eaton, Simon
actors_id: SEATO65
actors_role: owner
full_text_status: public
publication: BMJ Paediatrics Open
volume: 1
number: e000151
issn: 2399-9772
citation:        Sherratt, FC;    Eaton, SJ;    Walker, E;    Beasant, L;    Blazeby, JM;    Young, B;    Crawley, E;         ... Hall, NJ; + view all <#>        Sherratt, FC;  Eaton, SJ;  Walker, E;  Beasant, L;  Blazeby, JM;  Young, B;  Crawley, E;  Wood, W;  Hall, NJ;   - view fewer <#>    (2017)    Development of a core outcome set to determine the overall treatment success of acute uncomplicated appendicitis in children: a study protocol.                   BMJ Paediatrics Open , 1  (e000151)      10.1136/bmjpo-2017-000151 <https://doi.org/10.1136/bmjpo-2017-000151>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1566608/8/Sherratt_development_of_a_core_outcome_set.pdf