TY  - JOUR
N1  - This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TI  - Evaluation of Haemoglobin and Cytochrome Responses During Forearm Ischaemia Using Multi-wavelength Time Domain NIRS
EP  - 72
AV  - public
SP  - 67
VL  - 977
Y1  - 2017/07/07/
JF  - Advances in Experimental Medicine and Biology
KW  - Cuff Occlusion
KW  -  Cytochrome-c-oxidase
KW  -  Haemoglobin
KW  -  NIRS
KW  -  TRS
A1  - Lange, F
A1  - Dunne, L
A1  - Tachtsidis, I
ID  - discovery1566572
N2  - We demonstrate the ability of a 16-wavelength time domain near-infrared spectroscopy system to monitor changes in oxy- and deoxy haemoglobin ([HbO2] [HHb]) and the oxidation of cytochrome-c-oxidase ([oxCCO]), during forearm ischaemia. We tested two methods to retrieve the concentration changes. The first uses the measured changes in light attenuation and the modified Beer-Lambert law, and the second uses the absorption and scattering estimated by the measured time-point spread function. The system is able to retrieve the concentration changes with both methods, giving similar results. At the end of forearm ischaemia (t = 5 min), we measured an increase in [HHb] of 16.77 ± 2.52 and 16.37 ± 2.33 ?Mol, and a decrease in [HbO2] of -6.12 ± 1.62 and -5.57 ± 2.02 ?Mol for method 1 and 2, respectively. At that same time, the changes in [oxCCO] were -0.36 ± 0.33 and -1.40 ± 1.20 ?Mol, for method 1 and 2, respectively. These small changes in [oxCCO], despite a huge change in haemoglobin, demonstrate the absence of crosstalk and are comparable to previous measurements using broadband NIRS.
SN  - 0065-2598
UR  - http://doi.org/10.1007/978-3-319-55231-6_10
ER  -