TY  - JOUR
TI  - Bilateral Wilms tumour: a review of clinical and molecular features
AV  - public
Y1  - 2017/07/18/
VL  - 19
EP  - 13
N1  - © Cambridge University Press 2017.
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
N2  - Wilms tumour (WT) is the most common paediatric kidney cancer and affects approximately one in 10 000 children.
The tumour is associated with undifferentiated embryonic lesions called nephrogenic rests (NRs) or, when diffuse,
nephroblastomatosis. WT or NRs can occur in both kidneys, termed bilateral disease, found in only 5?8% of cases.
Management of bilateral WT presents a major clinical challenge in terms of maximising survival, preserving renal
function and understanding underlying genetic risk. In this review, we compile clinical data from 545 published
cases of bilateral WT and discuss recent progress in understanding the molecular basis of bilateral WT and its
associated precursor NRs in the context of the latest radiological, surgical and epidemiological features.
ID  - discovery1560517
PB  - CAMBRIDGE UNIV PRESS
UR  - http://doi.org/10.1017/erm.2017.8
SN  - 1462-3994
JF  - Expert Reviews in Molecular Medicine
A1  - Charlton, J
A1  - Irtan, S
A1  - Bergeron, C
A1  - Pritchard-Jones, K
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Biochemistry & Molecular Biology
KW  -  Medicine
KW  -  Research & Experimental
KW  -  Research & Experimental Medicine
KW  -  NEPHRON-SPARING SURGERY
KW  -  SINGLE-CENTER EXPERIENCE
KW  -  APPARENT DIFFUSION-COEFFICIENT
KW  -  MOSAIC VARIEGATED ANEUPLOIDY
KW  -  BECKWITH-WIEDEMANN-SYNDROME
KW  -  CANCER-STUDY-GROUP
KW  -  OF-THE-LITERATURE
KW  -  ROUND-CELL TUMOR
KW  -  BETA-CATENIN
KW  -  IMAGING CHARACTERISTICS
ER  -