@article{discovery1560517,
            note = {{\copyright} Cambridge University Press 2017.
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.},
           month = {July},
          volume = {19},
         journal = {Expert Reviews in Molecular Medicine},
            year = {2017},
           title = {Bilateral Wilms tumour: a review of clinical and molecular features},
       publisher = {CAMBRIDGE UNIV PRESS},
            issn = {1462-3994},
        abstract = {Wilms tumour (WT) is the most common paediatric kidney cancer and affects approximately one in 10 000 children.
The tumour is associated with undifferentiated embryonic lesions called nephrogenic rests (NRs) or, when diffuse,
nephroblastomatosis. WT or NRs can occur in both kidneys, termed bilateral disease, found in only 5-8\% of cases.
Management of bilateral WT presents a major clinical challenge in terms of maximising survival, preserving renal
function and understanding underlying genetic risk. In this review, we compile clinical data from 545 published
cases of bilateral WT and discuss recent progress in understanding the molecular basis of bilateral WT and its
associated precursor NRs in the context of the latest radiological, surgical and epidemiological features.},
          author = {Charlton, J and Irtan, S and Bergeron, C and Pritchard-Jones, K},
             url = {http://doi.org/10.1017/erm.2017.8},
        keywords = {Science \& Technology, Life Sciences \& Biomedicine, Biochemistry \& Molecular Biology, Medicine, Research \& Experimental, Research \& Experimental Medicine, NEPHRON-SPARING SURGERY, SINGLE-CENTER EXPERIENCE, APPARENT DIFFUSION-COEFFICIENT, MOSAIC VARIEGATED ANEUPLOIDY, BECKWITH-WIEDEMANN-SYNDROME, CANCER-STUDY-GROUP, OF-THE-LITERATURE, ROUND-CELL TUMOR, BETA-CATENIN, IMAGING CHARACTERISTICS}
}