eprintid: 1559744
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/01/55/97/44
datestamp: 2017-06-18 01:05:53
lastmod: 2021-09-20 00:05:42
status_changed: 2017-07-14 09:24:22
type: article
metadata_visibility: show
creators_name: Stanford, SC
title: Confusing preclinical (predictive) drug screens with animal "models' of psychiatric disorders, or "disorder-like' behaviour, is undermining confidence in behavioural neuroscience
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Preclinical (predictive) screens for psychotropic drugs are often used, incorrectly, as animal ‘models’ of psychiatric disorders, or to study ‘disorder-like’
behaviours. This misunderstanding is contributing to poor translation and is undermining confidence in behavioural neuroscience. In this editorial, I
discuss some of the reasons why the interpretation of results from many of these procedures is dubious because the criteria for validity of the test, as
a model of the disorder, have been ignored. Arising from this, I propose that the description of any abnormal behaviour of rodents as a ‘model’ of a
psychiatric disorder, or even ‘disorder-like’, without evidence-based justification, should be regarded as unacceptable in this journal.
date: 2017-06-01
date_type: published
publisher: SAGE PUBLICATIONS LTD
official_url: http://doi.org/10.1177/0269881116689260
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
article_type: editorial_comment
verified: verified_manual
elements_id: 1298547
doi: 10.1177/0269881116689260
lyricists_name: Stanford, Susan
lyricists_id: SCSTA01
actors_name: Waragoda Vitharana, Nimal
actors_id: NWARR44
actors_role: owner
full_text_status: public
publication: Journal of Psychopharmacology
volume: 31
number: 6
pagerange: 641-643
pages: 3
issn: 1461-7285
citation:        Stanford, SC;      (2017)    Confusing preclinical (predictive) drug screens with animal "models' of psychiatric disorders, or "disorder-like' behaviour, is undermining confidence in behavioural neuroscience.           [Editorial comment].        Journal of Psychopharmacology , 31  (6)   pp. 641-643.    10.1177/0269881116689260 <https://doi.org/10.1177/0269881116689260>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1559744/1/Stanford_accepted%20editorial.pdf