<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/1559696> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/title> "The fate and lifespan of human monocyte subsets in steady state and systemic inflammation"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/abstract> "In humans, the monocyte pool comprises three subsets (classical, intermediate, and nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, differentiation, and disappearance are critical to understanding both steady-state homeostasis and inflammatory responses. Here, using human in vivo deuterium labeling, we demonstrate that classical monocytes emerge first from marrow, after a postmitotic interval of 1.6 d, and circulate for a day. Subsequent labeling of intermediate and nonclassical monocytes is consistent with a model of sequential transition. Intermediate and nonclassical monocytes have longer circulating lifespans (∼4 and ∼7 d, respectively). In a human experimental endotoxemia model, a transient but profound monocytopenia was observed; restoration of circulating monocytes was achieved by the early release of classical monocytes from bone marrow. The sequence of repopulation recapitulated the order of maturation in healthy homeostasis. This developmental relationship between monocyte subsets was verified by fate mapping grafted human classical monocytes into humanized mice, which were able to differentiate sequentially into intermediate and nonclassical cells."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/date> "2017-07-03" .
<https://discovery.ucl.ac.uk/id/document/1021282> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/volume> "214" .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/issue> "7" .
<https://discovery.ucl.ac.uk/id/publication/ext-00221007> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-00221007> <http://xmlns.com/foaf/0.1/name> "Journal of Experimental Medicine"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-00221007> .
<https://discovery.ucl.ac.uk/id/publication/ext-00221007> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:00221007> .
<https://discovery.ucl.ac.uk/id/publication/ext-00221007> <http://purl.org/ontology/bibo/issn> "00221007" .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-23852f640af8721abd24543714357c7f> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-23852f640af8721abd24543714357c7f> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2e1127a091f0cee06f450a82850163bf> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-2e1127a091f0cee06f450a82850163bf> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-de7a36d4a794c5f57fa7b3ee6e751a19> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-de7a36d4a794c5f57fa7b3ee6e751a19> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-32df5be251079cd55762abfe2031e69a> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-32df5be251079cd55762abfe2031e69a> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d877a1bdb73cae63c9c165c0ee8ed232> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-d877a1bdb73cae63c9c165c0ee8ed232> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-87a8dee580908b0ec9505b9fc115cdfb> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-87a8dee580908b0ec9505b9fc115cdfb> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-801c2dfc9b4fc85e9a176f1999b6a423> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-801c2dfc9b4fc85e9a176f1999b6a423> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-68e37f3f413e79cbf4130a78754cbbe8> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-68e37f3f413e79cbf4130a78754cbbe8> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ffc7a1d5826f79e167627caa90b82064> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-ffc7a1d5826f79e167627caa90b82064> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1ec912bc2971cf4ce57cbf70baf1f64b> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-1ec912bc2971cf4ce57cbf70baf1f64b> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d63c74ec20a5ac3c0416f6f230e53087> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-d63c74ec20a5ac3c0416f6f230e53087> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a2f42bf3231bda060ff80851672984f5> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/1559696#authors> .
<https://discovery.ucl.ac.uk/id/eprint/1559696#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-a2f42bf3231bda060ff80851672984f5> .
<https://discovery.ucl.ac.uk/id/person/ext-de7a36d4a794c5f57fa7b3ee6e751a19> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-de7a36d4a794c5f57fa7b3ee6e751a19> <http://xmlns.com/foaf/0.1/givenName> "JN"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de7a36d4a794c5f57fa7b3ee6e751a19> <http://xmlns.com/foaf/0.1/familyName> "Fullerton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de7a36d4a794c5f57fa7b3ee6e751a19> <http://xmlns.com/foaf/0.1/name> "JN Fullerton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d63c74ec20a5ac3c0416f6f230e53087> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d63c74ec20a5ac3c0416f6f230e53087> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d63c74ec20a5ac3c0416f6f230e53087> <http://xmlns.com/foaf/0.1/familyName> "Macallan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d63c74ec20a5ac3c0416f6f230e53087> <http://xmlns.com/foaf/0.1/name> "D Macallan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1ec912bc2971cf4ce57cbf70baf1f64b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1ec912bc2971cf4ce57cbf70baf1f64b> <http://xmlns.com/foaf/0.1/givenName> "B"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1ec912bc2971cf4ce57cbf70baf1f64b> <http://xmlns.com/foaf/0.1/familyName> "Asquith"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1ec912bc2971cf4ce57cbf70baf1f64b> <http://xmlns.com/foaf/0.1/name> "B Asquith"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-68e37f3f413e79cbf4130a78754cbbe8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-68e37f3f413e79cbf4130a78754cbbe8> <http://xmlns.com/foaf/0.1/givenName> "RA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-68e37f3f413e79cbf4130a78754cbbe8> <http://xmlns.com/foaf/0.1/familyName> "Flavell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-68e37f3f413e79cbf4130a78754cbbe8> <http://xmlns.com/foaf/0.1/name> "RA Flavell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a2f42bf3231bda060ff80851672984f5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a2f42bf3231bda060ff80851672984f5> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a2f42bf3231bda060ff80851672984f5> <http://xmlns.com/foaf/0.1/familyName> "Yona"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a2f42bf3231bda060ff80851672984f5> <http://xmlns.com/foaf/0.1/name> "S Yona"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-801c2dfc9b4fc85e9a176f1999b6a423> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-801c2dfc9b4fc85e9a176f1999b6a423> <http://xmlns.com/foaf/0.1/givenName> "V"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-801c2dfc9b4fc85e9a176f1999b6a423> <http://xmlns.com/foaf/0.1/familyName> "Bigley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-801c2dfc9b4fc85e9a176f1999b6a423> <http://xmlns.com/foaf/0.1/name> "V Bigley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-23852f640af8721abd24543714357c7f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-23852f640af8721abd24543714357c7f> <http://xmlns.com/foaf/0.1/givenName> "AA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-23852f640af8721abd24543714357c7f> <http://xmlns.com/foaf/0.1/familyName> "Patel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-23852f640af8721abd24543714357c7f> <http://xmlns.com/foaf/0.1/name> "AA Patel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d877a1bdb73cae63c9c165c0ee8ed232> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d877a1bdb73cae63c9c165c0ee8ed232> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d877a1bdb73cae63c9c165c0ee8ed232> <http://xmlns.com/foaf/0.1/familyName> "Rongvaux"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d877a1bdb73cae63c9c165c0ee8ed232> <http://xmlns.com/foaf/0.1/name> "A Rongvaux"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2e1127a091f0cee06f450a82850163bf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2e1127a091f0cee06f450a82850163bf> <http://xmlns.com/foaf/0.1/givenName> "Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2e1127a091f0cee06f450a82850163bf> <http://xmlns.com/foaf/0.1/familyName> "Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2e1127a091f0cee06f450a82850163bf> <http://xmlns.com/foaf/0.1/name> "Y Zhang"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ffc7a1d5826f79e167627caa90b82064> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ffc7a1d5826f79e167627caa90b82064> <http://xmlns.com/foaf/0.1/givenName> "DW"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ffc7a1d5826f79e167627caa90b82064> <http://xmlns.com/foaf/0.1/familyName> "Gilroy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ffc7a1d5826f79e167627caa90b82064> <http://xmlns.com/foaf/0.1/name> "DW Gilroy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-32df5be251079cd55762abfe2031e69a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-32df5be251079cd55762abfe2031e69a> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-32df5be251079cd55762abfe2031e69a> <http://xmlns.com/foaf/0.1/familyName> "Boelen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-32df5be251079cd55762abfe2031e69a> <http://xmlns.com/foaf/0.1/name> "L Boelen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-87a8dee580908b0ec9505b9fc115cdfb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-87a8dee580908b0ec9505b9fc115cdfb> <http://xmlns.com/foaf/0.1/givenName> "AA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-87a8dee580908b0ec9505b9fc115cdfb> <http://xmlns.com/foaf/0.1/familyName> "Maini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-87a8dee580908b0ec9505b9fc115cdfb> <http://xmlns.com/foaf/0.1/name> "AA Maini"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/1559696> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1021282> .
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