eprintid: 1559687 rev_number: 28 eprint_status: archive userid: 608 dir: disk0/01/55/96/87 datestamp: 2017-06-18 00:07:41 lastmod: 2021-09-20 00:04:36 status_changed: 2017-07-05 09:45:12 type: article metadata_visibility: show creators_name: Arber, C creators_name: Lovejoy, C creators_name: Wray, S title: Stem cell models of Alzheimer's disease: progress and challenges. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F86 divisions: C08 divisions: D09 keywords: 3D cerebral organoids, Alzheimer’s disease, Induced pluripotent stem cells, Neuronal differentiation note: © The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. abstract: A major challenge to our understanding of the molecular mechanisms of Alzheimer's disease (AD) has been the lack of physiologically relevant in vitro models which capture the precise patient genome, in the cell type of interest, with physiological expression levels of the gene(s) of interest. Induced pluripotent stem cell (iPSC) technology, together with advances in 2D and 3D neuronal differentiation, offers a unique opportunity to overcome this challenge and generate a limitless supply of human neurons for in vitro studies. iPSC-neuron models have been widely employed to model AD and we discuss in this review the progress that has been made to date using patient-derived neurons to recapitulate key aspects of AD pathology and how these models have contributed to a deeper understanding of AD molecular mechanisms, as well as addressing the key challenges posed by using this technology and what progress is being made to overcome these. Finally, we highlight future directions for the use of iPSC-neurons in AD research and highlight the potential value of this technology to neurodegenerative research in the coming years. date: 2017-06-13 date_type: published official_url: http://dx.doi.org/10.1186/s13195-017-0268-4 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1298402 doi: 10.1186/s13195-017-0268-4 pii: 10.1186/s13195-017-0268-4 language_elements: eng lyricists_name: Arber, Charles lyricists_name: Lovejoy, Christopher lyricists_name: Wray, Selina lyricists_id: CARBE72 lyricists_id: CEJLO68 lyricists_id: SWRAY93 full_text_status: public publication: Alzheimer's Research & Therapy volume: 9 number: 1 article_number: 42 event_location: England issn: 1758-9193 citation: Arber, C; Lovejoy, C; Wray, S; (2017) Stem cell models of Alzheimer's disease: progress and challenges. Alzheimer's Research & Therapy , 9 (1) , Article 42. 10.1186/s13195-017-0268-4 <https://doi.org/10.1186/s13195-017-0268-4>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1559687/1/Arber_Stem%20cell%20models%20of%20Alzheimer%27s%20disease%253A%20progress%20and%20challenges.pdf