eprintid: 1559687
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/01/55/96/87
datestamp: 2017-06-18 00:07:41
lastmod: 2021-09-20 00:04:36
status_changed: 2017-07-05 09:45:12
type: article
metadata_visibility: show
creators_name: Arber, C
creators_name: Lovejoy, C
creators_name: Wray, S
title: Stem cell models of Alzheimer's disease: progress and challenges.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
divisions: C08
divisions: D09
keywords: 3D cerebral organoids, Alzheimer’s disease, Induced pluripotent stem cells, Neuronal differentiation
note: © The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
abstract: A major challenge to our understanding of the molecular mechanisms of Alzheimer's disease (AD) has been the lack of physiologically relevant in vitro models which capture the precise patient genome, in the cell type of interest, with physiological expression levels of the gene(s) of interest. Induced pluripotent stem cell (iPSC) technology, together with advances in 2D and 3D neuronal differentiation, offers a unique opportunity to overcome this challenge and generate a limitless supply of human neurons for in vitro studies. iPSC-neuron models have been widely employed to model AD and we discuss in this review the progress that has been made to date using patient-derived neurons to recapitulate key aspects of AD pathology and how these models have contributed to a deeper understanding of AD molecular mechanisms, as well as addressing the key challenges posed by using this technology and what progress is being made to overcome these. Finally, we highlight future directions for the use of iPSC-neurons in AD research and highlight the potential value of this technology to neurodegenerative research in the coming years.
date: 2017-06-13
date_type: published
official_url: http://dx.doi.org/10.1186/s13195-017-0268-4
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Journal Article
verified: verified_manual
elements_id: 1298402
doi: 10.1186/s13195-017-0268-4
pii: 10.1186/s13195-017-0268-4
language_elements: eng
lyricists_name: Arber, Charles
lyricists_name: Lovejoy, Christopher
lyricists_name: Wray, Selina
lyricists_id: CARBE72
lyricists_id: CEJLO68
lyricists_id: SWRAY93
full_text_status: public
publication: Alzheimer's Research & Therapy
volume: 9
number: 1
article_number: 42
event_location: England
issn: 1758-9193
citation:        Arber, C;    Lovejoy, C;    Wray, S;      (2017)    Stem cell models of Alzheimer's disease: progress and challenges.                   Alzheimer's Research & Therapy , 9  (1)    , Article 42.  10.1186/s13195-017-0268-4 <https://doi.org/10.1186/s13195-017-0268-4>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/1559687/1/Arber_Stem%20cell%20models%20of%20Alzheimer%27s%20disease%253A%20progress%20and%20challenges.pdf