eprintid: 1559095 rev_number: 41 eprint_status: archive userid: 608 dir: disk0/01/55/90/95 datestamp: 2017-06-08 19:56:05 lastmod: 2021-12-10 01:04:15 status_changed: 2017-07-12 16:59:14 type: article metadata_visibility: show creators_name: Pavlova, AV creators_name: Saunders, FR creators_name: Muthuri, SG creators_name: Gregory, JS creators_name: Barr, RJ creators_name: Martin, KR creators_name: Hardy, RJ creators_name: Cooper, R creators_name: Adams, JE creators_name: Kuh, D creators_name: Aspden, RM title: Statistical shape modelling of hip and lumbar spine morphology and their relationship in the MRC National Survey of Health and Development ispublished: pub divisions: UCL divisions: B16 divisions: B14 divisions: J81 divisions: B02 divisions: D14 keywords: ageing, hip, lumbar spine, morphology, statistical shape modelling note: Copyright © 2017 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: The anatomical shape of bones and joints is important for their proper function but quantifying this, and detecting pathological variations, is difficult to do. Numerical descriptions would also enable correlations between joint shapes to be explored. Statistical shape modelling (SSM) is a method of image analysis employing pattern recognition statistics to describe and quantify such shapes from images; it uses principal components analysis to generate modes of variation describing each image in terms of a set of numerical scores after removing global size variation. We used SSM to quantify the shapes of the hip and the lumbar spine in dual-energy x-ray absorptiometry (DXA) images from 1511 individuals in the MRC National Survey of Health and Development at ages 60-64 years. We compared shapes of both joints in men and women and hypothesised that hip and spine shape would be strongly correlated. We also investigated associations with height, weight, body mass index (BMI) and local (hip or lumber spine) bone mineral density. In the hip, all except one of the first 10 modes differed between men and women. Men had a wider femoral neck, smaller neck-shaft angle, increased presence of osteophytes and a loss of the femoral head/neck curvature compared with women. Women presented with a flattening of the femoral head and greater acetabular coverage of the femoral head. Greater weight was associated with a shorter, wider femoral neck and larger greater and lesser trochanters. Taller height was accompanied by a flattening of the curve between superior head and neck and a larger lesser trochanter. Four of the first eight modes describing lumbar spine shape differed between men and women. Women tended to have a more lordotic spine than men with relatively smaller but caudally increasing anterior-posterior (a-p) vertebral diameters. Men were more likely to have a straighter spine with larger vertebral a-p diameters relative to vertebral height than women, increasing cranially. A weak correlation was found between body weight and a-p vertebral diameter. No correlations were found between shape modes and height in men, whereas in women there was a weak positive correlation between height and evenness of spinal curvature. Linear relationships between hip and spine shapes were weak and inconsistent in both sexes, thereby offering little support for our hypothesis. In conclusion, men and women entering their seventh decade have small but statistically significant differences in the shapes of their hips and their spines. Associations with height, weight, BMI and BMD are small and correspond to subtle variations whose anatomical significance is not yet clear. Correlations between hip and spine shapes are small. date: 2017-08 date_type: published official_url: http://dx.doi.org/10.1111/joa.12631 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green article_type_text: Journal Article verified: verified_manual elements_id: 1297148 doi: 10.1111/joa.12631 lyricists_name: Cooper, Rachel lyricists_name: Hardy, Rebecca lyricists_name: Kuh, Diana lyricists_name: Muthuri, Stella lyricists_id: RCOOP16 lyricists_id: RHARD63 lyricists_id: DKUHX97 lyricists_id: SGMUT15 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Journal of Anatomy volume: 231 number: 2 event_location: England issn: 1469-7580 citation: Pavlova, AV; Saunders, FR; Muthuri, SG; Gregory, JS; Barr, RJ; Martin, KR; Hardy, RJ; ... Aspden, RM; + view all <#> Pavlova, AV; Saunders, FR; Muthuri, SG; Gregory, JS; Barr, RJ; Martin, KR; Hardy, RJ; Cooper, R; Adams, JE; Kuh, D; Aspden, RM; - view fewer <#> (2017) Statistical shape modelling of hip and lumbar spine morphology and their relationship in the MRC National Survey of Health and Development. Journal of Anatomy , 231 (2) 10.1111/joa.12631 <https://doi.org/10.1111/joa.12631>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/1559095/1/Pavlova_Statistical_shape_modelling.pdf